PMID- 3333493
OWN - NLM
STAT- MEDLINE
DCOM- 19890327
LR  - 20051116
VI  - 18
DP  - 1987
TI  - HTLV-I-associated myelopathy: an overview.
PG  - 181-6
AB  - From our past clinical observations, we have identified a cluster of cases with 
      distinct neurological manifestations and, together with our viral studies, it has 
      been proven that in fact these cases belong to a new clinical entity. The 
      association of this slowly progressive spastic paraparesis with human T-cell 
      lymphotropic virus type I (HTLV-I) enabled us to designate this clinical entity 
      as HTLV-I-associated myelopathy or HAM. Later studies showed that 1) the 
      geographical distribution of HAM follows that of adult T-cell leukemia (ATL) and 
      2) viruses detected in both disorders were identical by DNA blotting assay, but 
      HAM and ATL are definitely expressed clinically as distinct from the other. In 
      this regard, human leukocyte antigen (HLA) studies and the pattern of immune 
      responsiveness seem to show a clear segregation of one from the other. As many 
      initially studied cases have responded favorably to corticosteroids and had 
      frequent perivascular cuffing in the spinal cord of a necropsied case, it is 
      likely that, in part, immune events play a role in the pathogenesis. Our efforts 
      are now directed to determining whether a) HAM is purely an autoimmune process, 
      or b) a slow virus infection with a long incubation period may be the culprit.
FAU - Igata, A
AU  - Igata A
AD  - Kagoshima University, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Princess Takamatsu Symp
JT  - Princess Takamatsu symposia
JID - 9301172
SB  - IM
MH  - HTLV-I Infections/*complications
MH  - Human T-lymphotropic virus 1/pathogenicity
MH  - Humans
MH  - Spinal Cord Diseases/*etiology/microbiology
RF  - 17
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
PST - ppublish
SO  - Princess Takamatsu Symp. 1987;18:181-6.