PMID- 33336253
OWN - NLM
STAT- MEDLINE
DCOM- 20211214
LR  - 20211218
IS  - 1537-6613 (Electronic)
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 224
IP  - 3
DP  - 2021 Aug 2
TI  - Disseminated Mycobacterium marinum in Human Immunodeficiency Virus Unmasked by 
      Immune Reconstitution Inflammatory Syndrome.
PG  - 453-457
LID - 10.1093/infdis/jiaa769 [doi]
AB  - Distinguishing disseminated Mycobacterium marinum from multifocal cutaneous 
      disease in persons with human immunodeficiency virus/AIDS can present a 
      diagnostic challenge, especially in the context of immune reconstitution 
      inflammatory syndrome (IRIS). In this work, we demonstrate the utility of flow 
      cytometry and whole genome sequencing (WGS) to diagnose disseminated M. marinum 
      unmasked by IRIS following initiation of antiretroviral therapy. Flow cytometry 
      demonstrated robust cytokine production by CD4 T cells in response to stimulation 
      with M. marinum lysate. WGS of isolates from distinct lesions was consistent with 
      clonal dissemination, supporting that preexisting disseminated M. marinum disease 
      was uncovered by inflammatory manifestations, consistent with unmasking 
      mycobacterial IRIS.
CI  - Published by Oxford University Press for the Infectious Diseases Society of 
      America 2020.
FAU - Manion, Maura
AU  - Manion M
AUID- ORCID: 0000-0003-0991-0011
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Dulanto Chiang, Augusto
AU  - Dulanto Chiang A
AUID- ORCID: 0000-0001-8040-9620
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Pei, Luxin
AU  - Pei L
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Wong, Chun-Shu
AU  - Wong CS
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Khil, Pavel
AU  - Khil P
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
AD  - National Human Genome Research Institute, National Institutes of Health, 
      Bethesda, Maryland, USA.
FAU - Hammoud, Dima A
AU  - Hammoud DA
AD  - Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical 
      Center, NIH, Bethesda, Maryland, USA.
FAU - Anderson, Megan
AU  - Anderson M
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Laidlaw, Elizabeth
AU  - Laidlaw E
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Kuriakose, Safia
AU  - Kuriakose S
AD  - Clinical Research Directorate, Frederick National Laboratory for Cancer Research 
      sponsored by the National Cancer Institute, Frederick, Maryland, USA.
FAU - Lisco, Andrea
AU  - Lisco A
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
CN  - NISC Comparative Sequencing Program
FAU - Zelazny, Adrian M
AU  - Zelazny AM
AD  - Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, Maryland, USA.
FAU - Dekker, John P
AU  - Dekker JP
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
FAU - Sereti, Irini
AU  - Sereti I
AUID- ORCID: 0000-0002-0076-0224
AD  - National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
LA  - eng
SI  - ClinicalTrials.gov/NCT02147405
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
SB  - IM
MH  - Antiretroviral Therapy, Highly Active
MH  - HIV
MH  - HIV Infections/complications/drug therapy
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/diagnosis/drug therapy
MH  - *Mycobacterium marinum
PMC - PMC8328204
OTO - NOTNLM
OT  - Mycobacterium marinum
OT  - HIV
OT  - IRIS
OT  - whole genome sequencing
EDAT- 2020/12/19 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/12/17
CRDT- 2020/12/18 05:54
PHST- 2020/10/20 00:00 [received]
PHST- 2020/12/16 00:00 [accepted]
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2020/12/18 05:54 [entrez]
PHST- 2021/12/17 00:00 [pmc-release]
AID - 6041190 [pii]
AID - jiaa769 [pii]
AID - 10.1093/infdis/jiaa769 [doi]
PST - ppublish
SO  - J Infect Dis. 2021 Aug 2;224(3):453-457. doi: 10.1093/infdis/jiaa769.