PMID- 33336255
OWN - NLM
STAT- MEDLINE
DCOM- 20210826
LR  - 20210826
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 156
IP  - 1
DP  - 2021 Jun 17
TI  - Perivascular Epithelioid Cell Tumor of Urinary Bladder.
PG  - 56-71
LID - 10.1093/ajcp/aqaa204 [doi]
AB  - OBJECTIVES: To review the clinicopathologic features of perivascular epithelioid 
      cell tumor (PEComa) of the urinary bladder. METHODS: Seven cases of bladder 
      PEComa were studied by light microscopy, immunohistochemistry, and fluorescence 
      in situ hybridization (FISH). RESULTS: In our 7 cases, 5 patients were female and 
      2 were male, with ages between 26 and 78 years. Patients presented with hematuria 
      and recurrent abdominal discomfort as the main clinical symptoms. 
      Microscopically, the epithelioid and spindle-shaped tumor cells with clear to 
      granular eosinophilic cytoplasm were arranged in fascicular, acinar, or nested 
      patterns. The tumor cells were positive for HMB45, melan-A, and SMA, but no TFE3 
      gene rearrangement was detected in any of the 7 samples by FISH. The analysis of 
      all 35 cases from the literature and ours showed a patient age range from 16 to 
      78 years (mean age, 39 years), a male-to-female ratio of 1:1.3, maximal tumor 
      diameters from 0.6 to 18.8 cm (mean, 4.5 cm). With a mean follow-up of 27 months, 
      the recurrence, metastasis, and mortality rates were 10.7%, 10.7%, and 7.1%, 
      respectively. CONCLUSIONS: Bladder PEComa is extremely rare, remains a diagnostic 
      challenge, and needs more attention. Strengthening the understanding of this 
      tumor will improve diagnostic accuracy.
CI  - (c) American Society for Clinical Pathology, 2020. All rights reserved. For 
      permissions, please e-mail: journals.permissions@oup.com.
FAU - Wu, You-Li
AU  - Wu YL
AD  - Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
FAU - Lang, Lang
AU  - Lang L
AD  - Institute of Urology of PLA and Department of Urology, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
FAU - Ma, Qiang
AU  - Ma Q
AD  - Department of Pathology, Daping Hospital, Third Military Medical University (Army 
      Medical University), Chongqing, China.
FAU - Wu, Feng
AU  - Wu F
AD  - Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
FAU - Chen, Wei
AU  - Chen W
AD  - Department of Radiology, Southwest Hospital, Third Military Medical University 
      (Army Medical University), Chongqing, China.
FAU - Yan, Xiao-Chu
AU  - Yan XC
AD  - Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
FAU - Duan, Guang-Jie
AU  - Duan GJ
AUID- ORCID: 0000-0002-5564-4394
AD  - Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third 
      Military Medical University (Army Medical University), Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Perivascular Epithelioid Cell Neoplasms/*pathology
MH  - Urinary Bladder Neoplasms/*pathology
OTO - NOTNLM
OT  - Bladder
OT  - Diagnosis
OT  - FISH
OT  - PEComa
OT  - Perivascular epithelioid cell tumor
OT  - Prognosis
OT  - TFE3
OT  - Treatment
EDAT- 2020/12/19 06:00
MHDA- 2021/08/27 06:00
CRDT- 2020/12/18 05:54
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2021/08/27 06:00 [medline]
PHST- 2020/12/18 05:54 [entrez]
AID - 6041275 [pii]
AID - 10.1093/ajcp/aqaa204 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2021 Jun 17;156(1):56-71. doi: 10.1093/ajcp/aqaa204.