PMID- 33337028
OWN - NLM
STAT- MEDLINE
DCOM- 20210630
LR  - 20221005
IS  - 2162-3279 (Electronic)
VI  - 11
IP  - 2
DP  - 2021 Feb
TI  - Parcellation-based anatomic modeling of the default mode network.
PG  - e01976
LID - 10.1002/brb3.1976 [doi]
LID - e01976
AB  - BACKGROUND: The default mode network (DMN) is an important mediator of passive 
      states of mind. Multiple cortical areas, such as the anterior cingulate cortex, 
      posterior cingulate cortex, and lateral parietal lobe, have been linked in this 
      processing, though knowledge of network connectivity had limited tractographic 
      specificity. METHODS: Using resting-state fMRI studies related to the DMN, we 
      generated an activation likelihood estimation (ALE). We built a tractographical 
      model of this network based on the cortical parcellation scheme previously 
      published under the Human Connectome Project. DSI-based fiber tractography was 
      performed to determine the structural connections between cortical parcellations 
      comprising the network. RESULTS: Seventeen cortical regions were found to be part 
      of the DMN: 10r, 31a, 31pd, 31pv, a24, d23ab, IP1, p32, POS1, POS2, RSC, PFm, 
      PGi, PGs, s32, TPOJ3, and v23ab. These regions showed consistent interconnections 
      between adjacent parcellations, and the cingulum was found to connect the 
      anterior and posterior cingulate clusters within the network. CONCLUSIONS: We 
      present a preliminary anatomic model of the default mode network. Further studies 
      may refine this model with the ultimate goal of clinical application.
CI  - (c) 2020 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
FAU - Sandhu, Zainab
AU  - Sandhu Z
AD  - Department of Neurosurgery, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, USA.
FAU - Tanglay, Onur
AU  - Tanglay O
AUID- ORCID: 0000-0002-2071-6909
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Young, Isabella M
AU  - Young IM
AUID- ORCID: 0000-0001-7639-6679
AD  - Cingulum Health, Sydney, NSW, Australia.
FAU - Briggs, Robert G
AU  - Briggs RG
AD  - Department of Neurosurgery, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, USA.
FAU - Bai, Michael Y
AU  - Bai MY
AUID- ORCID: 0000-0002-5764-7740
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Larsen, Micah L
AU  - Larsen ML
AD  - Department of Neurosurgery, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, USA.
FAU - Conner, Andrew K
AU  - Conner AK
AD  - Department of Neurosurgery, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, USA.
FAU - Dhanaraj, Vukshitha
AU  - Dhanaraj V
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Lin, Yueh-Hsin
AU  - Lin YH
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Hormovas, Jorge
AU  - Hormovas J
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Fonseka, Rannulu Dineth
AU  - Fonseka RD
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
FAU - Glenn, Chad A
AU  - Glenn CA
AD  - Department of Neurosurgery, University of Oklahoma Health Sciences Center, 
      Oklahoma City, OK, USA.
FAU - Sughrue, Michael E
AU  - Sughrue ME
AUID- ORCID: 0000-0001-5407-2585
AD  - Centre for Minimally Invasive Neurosurgery, Prince of Wales Private Hospital, 
      Sydney, NSW, Australia.
LA  - eng
GR  - U54 MH091657/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20201218
PL  - United States
TA  - Brain Behav
JT  - Brain and behavior
JID - 101570837
SB  - IM
MH  - *Connectome
MH  - *Default Mode Network
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Nerve Net/diagnostic imaging
MH  - Neural Pathways/diagnostic imaging
MH  - Parietal Lobe
PMC - PMC7882165
OTO - NOTNLM
OT  - ALE
OT  - anatomy
OT  - default mode network
OT  - parcellation
OT  - tractography
OT  - white matter
COIS- Dr. Sughrue is the Chief Medical Officer of Omniscient Neurotechnologies. No 
      products directly related to this were discussed in this paper. All other authors 
      have no financial interest or potential conflicts of interest.
EDAT- 2020/12/19 06:00
MHDA- 2021/07/01 06:00
PMCR- 2020/12/18
CRDT- 2020/12/18 08:39
PHST- 2020/07/16 00:00 [received]
PHST- 2020/11/04 00:00 [revised]
PHST- 2020/11/15 00:00 [accepted]
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2021/07/01 06:00 [medline]
PHST- 2020/12/18 08:39 [entrez]
PHST- 2020/12/18 00:00 [pmc-release]
AID - BRB31976 [pii]
AID - 10.1002/brb3.1976 [doi]
PST - ppublish
SO  - Brain Behav. 2021 Feb;11(2):e01976. doi: 10.1002/brb3.1976. Epub 2020 Dec 18.