PMID- 33337838
OWN - NLM
STAT- MEDLINE
DCOM- 20210527
LR  - 20210527
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 66
IP  - 12
DP  - 2020 Dec 1
TI  - Associations of Changes in Serum Inflammatory Factors, MMP-3, 25(OH)D and 
      Intestinal Flora with Osteoporosis and Disease Activity in Rheumatoid Arthritis 
      Patients.
LID - 10.7754/Clin.Lab.2020.200242 [doi]
AB  - BACKGROUND: To explore the associations of changes in serum inflammatory factors, 
      matrix metalloproteinase-3 (MMP-3), 25-hydroxy vitamin D [25(OH)D], and 
      intestinal flora with osteoporosis and disease activity in rheumatoid arthritis 
      (RA) patients, so as to provide references for clinical diagnosis and treatment. 
      METHODS: A total of 98 RA patients were selected as the objects of study (RA 
      group), and divided into active-stage group (n = 56) and remission-stage group (n 
      = 42) according to the disease activity score (DAS28). Another 50 healthy people 
      receiving physical examination in our hospital during the same period were 
      selected as the control group. The changes in serum inflammatory factors, MMP-3, 
      25(OH)D, and intestinal flora were compared among the three groups, and the 
      osteoporosis of the subjects was analyzed in each group. Moreover, the 
      associations of changes in serum inflammatory factors, MMP-3, 25(OH)D, and 
      intestinal flora with osteoporosis and disease activity in RA patients were 
      analyzed using the Pearson's method. RESULTS: Compared with those in the control 
      group, the levels of serum MMP-3, interleukin-6 (IL-6), IL-10, and C-reactive 
      protein (CRP). The Escherichia coli count were significantly increased, while the 
      level of serum 25(OH)D, bone mineral density (BMD), and Lactobacillus and 
      Bifidobacterium counts were significantly decreased in the active-stage group and 
      remission-stage group, more obviously in active-stage group (p < 0.05). The 
      osteoporosis and disease activity in RA patients were positively correlated with 
      serum IL-6, IL-10, CRP, MMP-3, Escherichia coli and BMD, but negatively 
      correlated with 25(OH)D, Lactobacillus and Bifidobacterium (p < 0.05), and not 
      correlated with the sharp score (p > 0.05). CONCLUSIONS: There are certain 
      associations of changes in serum inflammatory factors, MMP-3, 25(OH)D, and 
      in-testinal flora with osteoporosis and disease activity in RA patients, showing 
      certain value in clinical application.
FAU - Yong, Wang
AU  - Yong W
FAU - Hongbin, Li
AU  - Hongbin L
FAU - Jing, Wang
AU  - Jing W
FAU - Jing, Zhao
AU  - Jing Z
FAU - Ning, Tie
AU  - Ning T
FAU - Lijie, Bai
AU  - Lijie B
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - *Arthritis, Rheumatoid/diagnosis
MH  - *Gastrointestinal Microbiome
MH  - Humans
MH  - *Matrix Metalloproteinase 3/blood
MH  - *Osteoporosis/diagnosis/genetics/microbiology
MH  - Vitamin D/*analogs & derivatives/blood
EDAT- 2020/12/19 06:00
MHDA- 2021/05/28 06:00
CRDT- 2020/12/18 16:32
PHST- 2020/12/18 16:32 [entrez]
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2021/05/28 06:00 [medline]
AID - 10.7754/Clin.Lab.2020.200242 [doi]
PST - ppublish
SO  - Clin Lab. 2020 Dec 1;66(12). doi: 10.7754/Clin.Lab.2020.200242.