PMID- 33338029
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210306
IS  - 2049-3614 (Print)
IS  - 2049-3614 (Electronic)
IS  - 2049-3614 (Linking)
VI  - 10
IP  - 1
DP  - 2021 Jan
TI  - New insights into the links between anti-diabetes drugs and gut microbiota.
PG  - R36-R42
LID - EC-20-0431 [pii]
LID - 10.1530/EC-20-0431 [doi]
AB  - In patients with type 2 diabetes mellitus (T2DM), the intestinal flora is out of 
      balance and accompanied by leaky gut. The flora is characterized by an increase 
      in mucus-degrading bacteria and a decrease in fiber-degrading bacteria. 
      Short-chain fatty acids (SCFAs), as the major fiber-degrading bacteria 
      fermentation, not only ameliorate the leaky gut, but also activate GPR43 to 
      increase the mass of functional pancreatic beta-cells and exert anti-inflammation 
      effect. At present, the gut microbiota is considered as the potential target for 
      anti-diabetes drugs, and how to reverse the imbalance of gut microbiota has 
      become a therapeutic strategy for T2DM. This review briefly summarizes the drugs 
      or compounds that have direct or potential therapeutic effects on T2DM by 
      modulating the gut microbiota, including biguanides, isoquinoline alkaloids, 
      stilbene and C7N-aminocyclic alcohols.
FAU - Hu, Ruixin
AU  - Hu R
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
FAU - Yuan, Yanting
AU  - Yuan Y
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
FAU - Liu, Chaolong
AU  - Liu C
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
FAU - Zhou, Ji
AU  - Zhou J
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
FAU - Ji, Lixia
AU  - Ji L
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
FAU - Jiang, Guohui
AU  - Jiang G
AD  - School of pharmacy, Qing Dao University, Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Endocr Connect
JT  - Endocrine connections
JID - 101598413
PMC - PMC7923145
OTO - NOTNLM
OT  - anti-diabetes drugs
OT  - functional pancreatic beta-cells
OT  - gut microbiota
OT  - leaky gut
OT  - short-chain fatty acids (SCFAs)
OT  - type 2 diabetes mellitus (T2DM)
EDAT- 2020/12/19 06:00
MHDA- 2020/12/19 06:01
PMCR- 2020/12/17
CRDT- 2020/12/18 17:10
PHST- 2020/12/09 00:00 [received]
PHST- 2020/12/17 00:00 [accepted]
PHST- 2020/12/19 06:00 [pubmed]
PHST- 2020/12/19 06:01 [medline]
PHST- 2020/12/18 17:10 [entrez]
PHST- 2020/12/17 00:00 [pmc-release]
AID - EC-20-0431 [pii]
AID - 10.1530/EC-20-0431 [doi]
PST - ppublish
SO  - Endocr Connect. 2021 Jan;10(1):R36-R42. doi: 10.1530/EC-20-0431.