PMID- 33339120
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201229
IS  - 2075-4426 (Print)
IS  - 2075-4426 (Electronic)
IS  - 2075-4426 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Dec 16
TI  - Brain Responses to Emotional Stimuli after Eicosapentaenoic Acid and 
      Docosahexaenoic Acid Treatments in Major Depressive Disorder: Toward Personalized 
      Medicine with Anti-Inflammatory Nutraceuticals.
LID - 10.3390/jpm10040283 [doi]
LID - 283
AB  - N-3 polyunsaturated fatty acid supplements improve the symptoms of major 
      depressive disorder (MDD) in randomized-controlled trials and meta-analyses, with 
      the higher efficacy from anti-inflammatory eicosapentaenoic acid (EPA) than 
      brain-dominant docosahexaenoic acid (DHA). To investigate the specific brain 
      mechanisms of the anti-inflammatory anti-depressant nutraceutical compounds, we 
      recruited 24 MDD subjects in this double-blind, head-to-head study with a 12-week 
      EPA or DHA treatment (clinical trial registration number: NCT03871088). The 
      depression severity was assessed by Hamilton depression rating scale (HAM-D). 
      Brain responses to emotional stimuli were measured by a 3-Tesla MRI. The 
      correlation between HAM-D scores and brain responses also were tested. Compared 
      to 18 healthy controls, the brain responses of untreated 24 MDD patients mainly 
      revealed hypoactivity in the regions associated with emotion perception and 
      emotion control when processing positive emotion. After treatment, more remitted 
      MDD patients have been observed in the EPA as compared to the DHA groups. In 
      addition, the EPA, but not DHA, treatment revealed increased activity in the 
      regions associated with emotion perception and cognitive control when processing 
      positive emotion. The correlation analysis further revealed negative correlation 
      between HAM-D scores and brain responses in cognitive control regions. The 
      results of this study may imply the compensatory brain responses of cognitive and 
      emotion controls by EPA but not DHA and underpin personalized medicine with 
      anti-inflammatory nutraceuticals toward depression treatments.
FAU - Tu, Cheng-Hao
AU  - Tu CH
AUID- ORCID: 0000-0002-7695-5570
AD  - Graduate Institute of Acupuncture Science, China Medical University, Taichung 
      404333, Taiwan.
AD  - Mind-Body Interface Laboratory, Department of Psychiatry, China Medical 
      University Hospital, Taichung 404332, Taiwan.
FAU - Chen, Chun-Ming
AU  - Chen CM
AUID- ORCID: 0000-0003-3660-4511
AD  - Mind-Body Interface Laboratory, Department of Psychiatry, China Medical 
      University Hospital, Taichung 404332, Taiwan.
AD  - Department of Medical Imaging, China Medical University Hospital, Taichung 
      404332, Taiwan.
FAU - Yang, Chuan-Chih
AU  - Yang CC
AD  - Mind-Body Interface Laboratory, Department of Psychiatry, China Medical 
      University Hospital, Taichung 404332, Taiwan.
FAU - Galecki, Piotr
AU  - Galecki P
AUID- ORCID: 0000-0003-2447-5636
AD  - Department of Adult Psychiatry, Medical University of Lodz, 91-229 Lodz, Poland.
FAU - Su, Kuan-Pin
AU  - Su KP
AUID- ORCID: 0000-0002-4501-2502
AD  - Mind-Body Interface Laboratory, Department of Psychiatry, China Medical 
      University Hospital, Taichung 404332, Taiwan.
AD  - Graduate Institute of Biomedical Sciences, College of Medicine, China Medical 
      University, Taichung 404333, Taiwan.
AD  - An-Nan Hospital, China Medical University, Tainan 709204, Taiwan.
LA  - eng
GR  - MOST 106-2314-B-039-027-MY3, 108-2320-B-039-048, 108-2813-C-039-133-B, and 
      108-2314-B-039-016/Ministry of Science and Technology, Taiwan/
GR  - NHRI-EX108-10528NI/National Health Research Institutes, Taiwan/
GR  - ANHRF109-31/An Nan Hospital, China Medical University, Tainan, Taiwan/
GR  - CMRC-CMA-3/Higher Education Sprout Project by the Ministry of Education, Taiwan/
GR  - CMU108-SR-106/China Medical University, Taichung, Taiwan/
GR  - CMU104-S-16-01, CMU103-BC-4-1, CRS-108-048, DMR-108-216, DMR-109-102, 
      DMR-109-244, DMR-HHC-109-11, and DMR-HCC-109-12/China Medical University 
      Hospital, Taichung, Taiwan/
PT  - Journal Article
DEP - 20201216
PL  - Switzerland
TA  - J Pers Med
JT  - Journal of personalized medicine
JID - 101602269
PMC - PMC7765544
OTO - NOTNLM
OT  - docosahexaenoic acid (DHA)
OT  - eicosapentaenoic acid (EPA)
OT  - functional magnetic resonance imaging (fMRI)
OT  - major depressive disorder (MDD)
OT  - omega-3 polyunsaturated fatty acids (n-3 PUFAs)
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/20 06:00
MHDA- 2020/12/20 06:01
PMCR- 2020/12/16
CRDT- 2020/12/19 01:01
PHST- 2020/10/24 00:00 [received]
PHST- 2020/12/11 00:00 [revised]
PHST- 2020/12/12 00:00 [accepted]
PHST- 2020/12/19 01:01 [entrez]
PHST- 2020/12/20 06:00 [pubmed]
PHST- 2020/12/20 06:01 [medline]
PHST- 2020/12/16 00:00 [pmc-release]
AID - jpm10040283 [pii]
AID - jpm-10-00283 [pii]
AID - 10.3390/jpm10040283 [doi]
PST - epublish
SO  - J Pers Med. 2020 Dec 16;10(4):283. doi: 10.3390/jpm10040283.