PMID- 33340057
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20220501
IS  - 1435-1250 (Electronic)
IS  - 0340-1855 (Linking)
VI  - 81
IP  - 1
DP  - 2022 Feb
TI  - Serum vitamin D level correlates with disease activity and health-related quality 
      of life in antineutrophil cytoplasmic antibody-associated vasculitis.
PG  - 77-84
LID - 10.1007/s00393-020-00949-2 [doi]
AB  - BACKGROUND AND OBJECTIVE: The association between vitamin D levels and disease 
      activity has been established in patients with several autoimmune rheumatic 
      diseases. We aimed to examine the association between vitamin D and disease 
      activity of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). 
      METHODS: Fifty-four AAV patients and 50 age- and sex-matched healthy controls 
      without vitamin D supplements were included. Clinical and laboratory data were 
      evaluated during the assessment of vitamin D levels. Two different forms of 
      vitamin D in the sera-25(OH)D, which is the sum of 25(OH)D2 and 25(OH)D3, and 
      25(OH)D3, which only includes 25(OH)D in its D3 form-were measured, and the 
      relationship between vitamin D and the obtained data was assessed. Variations in 
      vitamin D levels relative to the season were also evaluated. RESULTS: Patients 
      with AAV demonstrated considerably lower 25(OH)D serum levels than healthy 
      controls (16.0 vs. 20.4 ng/mL, p = 0.016), and the proportion of individuals with 
      vitamin D deficiency was higher in patients with AAV than in healthy controls 
      (68.5% vs. 48.0%, p = 0.035). Both serum 25(OH)D and 25(OH)D3 were positively 
      associated with the 36-item Short-form Health Survey (SF-36) physical component 
      summary and SF-36 mental component summary (MCS) scores. A negative correlation 
      was observed between 25(OH)D and 25(OH)D3 serum levels and Birmingham vasculitis 
      activity score (BVAS), C‑reactive protein (CRP), and white blood cell count. 
      Linear regression analysis indicated haemoglobin and 25(OH)D levels to be 
      independently associated with BVAS and CRP and 25(OH)D levels with SF-36 MCS 
      score. No seasonal variations were observed in vitamin D levels. CONCLUSION: The 
      results from this study suggest that vitamin D levels could provide clinically 
      useful information in AAV.
CI  - (c) 2020. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
FAU - Yoon, T
AU  - Yoon T
AD  - Department of Medical Science, BK21 Plus Project, Yonsei University, College of 
      Medicine, Seoul, Korea (Republic of).
FAU - Ahn, S S
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic 
      of).
FAU - Pyo, J Y
AU  - Pyo JY
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic 
      of).
FAU - Song, J J
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic 
      of).
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (Republic of).
FAU - Park, Y-B
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic 
      of).
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (Republic of).
FAU - Lee, S-W
AU  - Lee SW
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, 03722, Seoul, Korea (Republic 
      of). sangwonlee@yuhs.ac.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea (Republic of). sangwonlee@yuhs.ac.
LA  - eng
PT  - Journal Article
TT  - Serum-Vitamin-D-Spiegel korreliert mit Krankheitsaktivitat und 
      gesundheitsbezogener Lebensqualitat bei 
      antineutrophile-zytoplasmatische-Antikorper-assoziierter Vaskulitis.
DEP - 20201218
PL  - Germany
TA  - Z Rheumatol
JT  - Zeitschrift fur Rheumatologie
JID - 0414162
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - *Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
MH  - *Antibodies, Antineutrophil Cytoplasmic
MH  - Humans
MH  - Prospective Studies
MH  - Quality of Life
MH  - Vitamin D
OTO - NOTNLM
OT  - 36-item short-form health survery
OT  - ANCA-associated vasculitides
OT  - Biomarker
OT  - Birmingham vasculitis activity score
OT  - Calcidiol
EDAT- 2020/12/20 06:00
MHDA- 2022/02/09 06:00
CRDT- 2020/12/19 05:29
PHST- 2020/11/30 00:00 [accepted]
PHST- 2020/12/20 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2020/12/19 05:29 [entrez]
AID - 10.1007/s00393-020-00949-2 [pii]
AID - 10.1007/s00393-020-00949-2 [doi]
PST - ppublish
SO  - Z Rheumatol. 2022 Feb;81(1):77-84. doi: 10.1007/s00393-020-00949-2. Epub 2020 Dec 
      18.