PMID- 33340760
OWN - NLM
STAT- MEDLINE
DCOM- 20210408
LR  - 20210408
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 535
DP  - 2021 Jan 8
TI  - Alleviation of the chronic stress response attributed to the antioxidant and 
      anti-inflammatory effects of electrolyzed hydrogen water.
PG  - 1-5
LID - S0006-291X(20)32212-9 [pii]
LID - 10.1016/j.bbrc.2020.12.035 [doi]
AB  - Reactive oxygen species (ROS) are highly reactive and directly attack surrounding 
      biomolecules to deteriorate cellular and tissue functions. Meanwhile, ROS also 
      serve as signaling mediators to upregulate pro-inflammatory cytokine expression 
      via activation of the nuclear factor kappa B signaling pathway, and the increased 
      pro-inflammatory cytokines trigger respiratory burst of inflammatory cells that 
      further accelerates ROS production in the inflamed tissue. Such crosstalk between 
      ROS and inflammatory responses leads to a chain reaction of negativity, and cause 
      progression of several chronic pathologies. Since molecular hydrogen is known to 
      preferentially remove cytotoxic hydroxyl radicals and peroxynitrites, and to 
      prevent cell and tissue damage, we here examined whether electrolyzed hydrogen 
      water (EHW) enriched with molecular hydrogen and reactive hydrogen storing 
      platinum nanoparticles dissolved from an electrode could alleviate oxidative 
      stress and inflammation induced by continuous stress challenges. Five-day 
      continuous stress loading to rats elevated reactive oxygen metabolites-derived 
      compounds (d-ROMs), interleukin (IL)-1beta, and adrenocorticotropic hormone (ACTH) 
      levels and decreased the biological antioxidant potential (BAP) level. Drinking 
      EHW during 5-day continuous stress loading significantly alleviated all of these 
      changes. The results suggest that EHW could suppress stress-response-associated 
      oxidative stress and IL-1beta level elevation in vivo, and that drinking of EHW is 
      effective for controlling stress responses via its antioxidant potential.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Hu, Di
AU  - Hu D
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Li, Danxi
AU  - Li D
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Shigeta, Mika
AU  - Shigeta M
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Ochi, Yuta
AU  - Ochi Y
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Okauchi, Takashi
AU  - Okauchi T
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Neyama, Hiroyuki
AU  - Neyama H
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
FAU - Kabayama, Shigeru
AU  - Kabayama S
AD  - Trim Medical Institute, Co. Ltd., Osaka, Japan.
FAU - Watanabe, Yasuyoshi
AU  - Watanabe Y
AD  - Laboratory for Pathophysiological and Health Science, RIKEN Center for Biosystems 
      Dynamics Research, Kobe, Japan. Electronic address: yywata@riken.jp.
FAU - Cui, Yilong
AU  - Cui Y
AD  - Laboratory for Biofunction Dynamics Imaging, RIKEN Center for Biosystems Dynamics 
      Research, Kobe, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201216
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Interleukin-18)
RN  - 0 (Reactive Oxygen Species)
RN  - 059QF0KO0R (Water)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Anti-Inflammatory Agents/*pharmacology
MH  - Antioxidants/*pharmacology
MH  - Electrodes
MH  - *Electrolysis
MH  - Hydrogen/administration & dosage/*pharmacology
MH  - Inflammation/blood/drug therapy/metabolism
MH  - Interleukin-18/blood
MH  - Male
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Reactive Oxygen Species/metabolism
MH  - Water/administration & dosage/*pharmacology
OTO - NOTNLM
OT  - ACTH
OT  - Continuous stress
OT  - Electrolyzed hydrogen water
OT  - IL-1beta
OT  - Oxidative stress
OT  - d-ROMs
COIS- Declaration of competing interest Y.W. and Y.C. received funding for the present 
      study from Nihon Trim Co. Ltd. S.K., PhD, is the employee of Trim Medical 
      Institute Co. Ltd. and the head of research group. However, this does not alter 
      our adherence to BBRC policies on sharing data and materials. The funders had no 
      role in the design of the study, in the collection, analyses, or interpretation 
      of data; in the writing of the manuscript, or in the decision to publish the 
      results.
EDAT- 2020/12/20 06:00
MHDA- 2021/04/10 06:00
CRDT- 2020/12/19 20:09
PHST- 2020/12/10 00:00 [received]
PHST- 2020/12/11 00:00 [accepted]
PHST- 2020/12/20 06:00 [pubmed]
PHST- 2021/04/10 06:00 [medline]
PHST- 2020/12/19 20:09 [entrez]
AID - S0006-291X(20)32212-9 [pii]
AID - 10.1016/j.bbrc.2020.12.035 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2021 Jan 8;535:1-5. doi: 10.1016/j.bbrc.2020.12.035. 
      Epub 2020 Dec 16.