PMID- 33341635 OWN - NLM STAT- MEDLINE DCOM- 20210119 LR - 20210119 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 760 DP - 2021 Mar 15 TI - Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China. PG - 143906 LID - S0048-9697(20)37437-4 [pii] LID - 10.1016/j.scitotenv.2020.143906 [doi] AB - Studies with multi-pollutant approach on the relationships between multiple metals and fasting plasma glucose (FPG) are limited. Few studies are available on the potential sex-specific associations between metal exposures and glucose metabolism. We explored the associations between 22 plasma metals and FPG level among the 769 participants from the manganese-exposed workers healthy cohort in China. We applied a sparse partial least squares (sPLS) regression followed by ordinary least-squares regression to evaluate multi-pollutant association. Bayesian kernel machine regression (BKMR) model was used to deal with metal mixtures and evaluate their joint effects on FPG level. In the sPLS model, negative associations on FPG levels were observed for plasma iron (belta = -0.066), cobalt (belta = -0.075), barium (belta = -0.109), and positive associations for strontium (belta = 0.082), and selenium (belta = 0.057) in men, which overlapped with the results among the overall participants. Among women, plasma copper (belta = 0.112) and antimony (belta = 0.137) were positively associated with elevated FPG level. Plasma magnesium was negatively associated with FPG level in both sexes (belta = -0.071 in men and belta = -0.144 in women). The results of overlapped for plasma magnesium was selected as the significant contributor to decreasing FPG level in the multi-pollutant, single-metal, and multi-metal models. BKMR model showed a significantly negative over-all effect of six metal mixtures (magnesium, iron, cobalt, selenium, strontium and barium) on FPG level among the overall participants from all the metals fixed at 50th percentile. In summary, our findings underline the probable role of metals in glucose homeostasis with potential sex-dependent heterogeneities, and suggest more researches are needed to explore the sex-specific associations of metal exposures with risk of diabetes. CI - Copyright (c) 2020 Elsevier B.V. All rights reserved. FAU - Ge, Xiaoting AU - Ge X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Yang, Aimin AU - Yang A AD - Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, SAR 999077, China. FAU - Huang, Sifang AU - Huang S AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Luo, Xiaoyu AU - Luo X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Hou, Qingzhi AU - Hou Q AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Huang, Lulu AU - Huang L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Zhou, Yanting AU - Zhou Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Li, Defu AU - Li D AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Lv, Yingnan AU - Lv Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Li, Longman AU - Li L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Chen, Xiang AU - Chen X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Zan, Gaohui AU - Zan G AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Tan, Yanli AU - Tan Y AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Liu, Chaoqun AU - Liu C AD - Department of Nutrition and Food Hygiene, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China. FAU - Xiao, Lili AU - Xiao L AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China. FAU - Zou, Yunfeng AU - Zou Y AD - Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China. FAU - Yang, Xiaobo AU - Yang X AD - Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning 530021, China; Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China; Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou 545006, Guangxi, China. Electronic address: yangx@gxmu.edu.cn. LA - eng PT - Journal Article DEP - 20201203 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - 0 (Blood Glucose) RN - 0 (Metals) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Bayes Theorem MH - Blood Glucose MH - China MH - Female MH - Glucose MH - Humans MH - Male MH - *Metals MH - *Plasma OTO - NOTNLM OT - Fasting plasma glucose OT - Joint effect OT - Metals OT - Occupation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2020/12/21 06:00 MHDA- 2021/01/20 06:00 CRDT- 2020/12/20 20:28 PHST- 2020/10/06 00:00 [received] PHST- 2020/11/17 00:00 [revised] PHST- 2020/11/18 00:00 [accepted] PHST- 2020/12/21 06:00 [pubmed] PHST- 2021/01/20 06:00 [medline] PHST- 2020/12/20 20:28 [entrez] AID - S0048-9697(20)37437-4 [pii] AID - 10.1016/j.scitotenv.2020.143906 [doi] PST - ppublish SO - Sci Total Environ. 2021 Mar 15;760:143906. doi: 10.1016/j.scitotenv.2020.143906. Epub 2020 Dec 3.