PMID- 33342789
OWN - NLM
STAT- MEDLINE
DCOM- 20210205
LR  - 20220419
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 16
IP  - 6
DP  - 2020 Oct-Dec
TI  - Synchronous bilateral breast cancer patients treated with hypofractionated 
      bilateral breast irradiation: A dosimetric and clinical study.
PG  - 1309-1313
LID - 10.4103/jcrt.JCRT_241_20 [doi]
AB  - BACKGROUND: Bilateral breast irradiation is technically challenging and there is 
      limited information regarding optimal technique and outcomes. Hypofractionated 
      Radiotherapy (HFRT) has emerged as the new standard of care in early breast 
      cancer. However, there are concerns in using hypofractionation for bilateral 
      breast irradiation due to larger volumes and potential toxicity. Our aim was to 
      analyze the dosimetric data and clinical outcomes in these patients. MATERIALS 
      AND METHODS: Patients with synchronous bilateral breast cancer (SBBC) treated 
      with bilateral breast irradiation were analyzed. All patients received 
      simultaneous bilateral breast with or without regional nodal irradiation using a 
      hypofractionated schedule of 40 Gy in 15 fractions over 3 weeks with single 
      isocenter bi-tangential field-in-field intensity-modulated radiation therapy 
      (FIF-IMRT) technique. RESULTS: Seven patients of SBBC were treated at our 
      institute from 2015 to 2017. All patients were postmenopausal females. Five 
      patients underwent bilateral modified radical mastectomy; two patients underwent 
      bilateral breast conservative surgery. All patients received systemic 
      anthracycline-based chemotherapy. The mean cardiac dose was 3.73 +/- Gy and V 25 
      was 3.26% +/- 1.96%. V 20 of lung ranged from 23.48% +/- 4.47% and the mean 
      esophageal dose was 3.6 +/- 2.00 Gy. No patient had acute toxicity higher than 
      Grade 2. At a median follow-up of 48 months, one patient died due to systemic 
      progression. No patient reported any late toxicity. CONCLUSION: Bilateral breast 
      irradiation using a hypofractionated schedule with single isocenter FIF-IMRT 
      technique is technically feasible with minimal acute toxicity and no significant 
      late effects on early follow-up.
FAU - Narasimhulu, B C
AU  - Narasimhulu BC
AD  - Department of Radiation Oncology, Government General Hospital, Guntur, Andhra 
      Pradesh,, India.
FAU - Valiyaveettil, Deepthi
AU  - Valiyaveettil D
AD  - Department of Radiation Oncology, Nizam's Institute of Medical Sciences, 
      Hyderabad, Telangana,, India.
FAU - Joseph, Deepa
AU  - Joseph D
AD  - Department of Radiation Oncology, All India Institute of Medical Sciences, 
      Rishikesh, Uttarakhand, India.
FAU - Ahmed, Syed Fayaz
AU  - Ahmed SF
AD  - Department of Radiation Oncology, Nizam's Institute of Medical Sciences, 
      Hyderabad, Telangana,, India.
FAU - Vijayakrishna, E
AU  - Vijayakrishna E
AD  - Department of Radiation Oncology, Nizam's Institute of Medical Sciences, 
      Hyderabad, Telangana,, India.
FAU - Malik, Monica
AU  - Malik M
AD  - Department of Radiation Oncology, Nizam's Institute of Medical Sciences, 
      Hyderabad, Telangana,, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/pathology/*radiotherapy
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Neoplasms, Multiple Primary/pathology/*radiotherapy
MH  - Radiation Dose Hypofractionation
MH  - Radiotherapy, Intensity-Modulated/methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Field-in-field intensity-modulated radiation therapy
OT  - hypofractionated radiotherapy
OT  - synchronous bilateral breast cancer
COIS- None
EDAT- 2020/12/22 06:00
MHDA- 2021/02/07 06:00
CRDT- 2020/12/21 06:01
PHST- 2020/12/21 06:01 [entrez]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2021/02/07 06:00 [medline]
AID - JCanResTher_2020_16_6_1309_303893 [pii]
AID - 10.4103/jcrt.JCRT_241_20 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2020 Oct-Dec;16(6):1309-1313. doi: 10.4103/jcrt.JCRT_241_20.