PMID- 33343878
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201222
IS  - 2045-8932 (Print)
IS  - 2045-8940 (Electronic)
IS  - 2045-8932 (Linking)
VI  - 10
IP  - 4
DP  - 2020 Oct-Dec
TI  - Pulmonary hypertension in patients with interstitial pneumonia with autoimmune 
      features.
PG  - 2045894020944117
LID - 10.1177/2045894020944117 [doi]
LID - 2045894020944117
AB  - Pulmonary hypertension in interstitial lung diseases is associated with increased 
      mortality and hospitalizations and reduced exercise capacity. Interstitial 
      pneumonia with autoimmune features (IPAF) is a recently described interstitial 
      lung disease. The characteristics of pulmonary hypertension in IPAF patients are 
      unknown. We sought to characterize patients with IPAF based on their 
      echocardiographic probability of pulmonary hypertension and compare patients with 
      and without pulmonary hypertension identified by right heart catheterization. We 
      conducted a retrospective study of patients seen in the interstitial lung disease 
      clinic from 2015 to 2018. Forty-seven patients with IPAF were identified. 
      Patients were classified into low, intermediate and high echocardiographic 
      pulmonary hypertension probabilities. A sub-group analysis of patients with 
      pulmonary hypertension and without pulmonary hypertension (IPAF-PH vs. IPAF-no 
      PH) identified by right heart catheterization was also performed. Linear 
      regression analysis was performed to study the association between 
      6-min-walk-distance (6MWD) and pulmonary vascular resistance (PVR) while 
      adjusting for age and body mass index. Right ventricular hypertrophy (>5 mm), 
      right ventricular enlargement (>41 mm) and right ventricular systolic dysfunction 
      defined as fractional area change% </=35 was present in 76%, 24%, and 39% of 
      patients, respectively. Pulmonary hypertension was identified in 12.7% of 
      patients. IPAF-PH patients had higher mean pulmonary artery pressure and lower 
      cardiac output compared to the IPAF-no PH group (34 mmHg vs. 19 mmHg, p = 0.002 
      and 4.0 vs. 5.7 L/min, p = 0.023, respectively). Lower 6MWD was associated with 
      higher PVR on regression analysis (p = 0.002). Pulmonologists should be aware 
      that a significant number of IPAF patients may develop pulmonary hypertension. 
      Reduced 6MWD may suggest the presence of pulmonary hypertension in IPAF patients.
CI  - (c) The Author(s) 2020.
FAU - Alzghoul, Bashar N
AU  - Alzghoul BN
AUID- ORCID: 0000-0002-4224-0892
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
FAU - Hamburger, Robert
AU  - Hamburger R
AD  - Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA. 
      RINGGOLD: 3463
FAU - Lewandowski, Thomas
AU  - Lewandowski T
AD  - Division of Cardiovascular Medicine, University of Florida, Gainesville, FL, USA. 
      RINGGOLD: 3463
FAU - Janssen, Brandon
AU  - Janssen B
AD  - Department of Internal Medicine, University of Florida, Gainesville, FL, USA. 
      RINGGOLD: 3463
FAU - Grey, Daniel
AU  - Grey D
AD  - Department of Internal Medicine, University of Florida, Gainesville, FL, USA. 
      RINGGOLD: 3463
FAU - Xue, Wei
AU  - Xue W
AD  - Department of Biostatistics, College of Public Health and Health Professions and 
      College of Medicine, University of Florida, Gainesville, FL, USA. RINGGOLD: 3463
FAU - Ataya, Ali
AU  - Ataya A
AUID- ORCID: 0000-0001-8505-1680
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
FAU - Alnuaimat, Hassan
AU  - Alnuaimat H
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
FAU - Gomez-Manjarres, Diana C
AU  - Gomez-Manjarres DC
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
FAU - Patel, Divya
AU  - Patel D
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
FAU - Reddy, Raju
AU  - Reddy R
AUID- ORCID: 0000-0002-3269-0136
AD  - Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, 
      Gainesville, FL, USA. RINGGOLD: 3463
LA  - eng
PT  - Journal Article
DEP - 20201207
PL  - United States
TA  - Pulm Circ
JT  - Pulmonary circulation
JID - 101557243
PMC - PMC7727068
OTO - NOTNLM
OT  - echocardiography
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune feature
OT  - pulmonary hypertension
OT  - six-min walk distance
EDAT- 2020/12/22 06:00
MHDA- 2020/12/22 06:01
PMCR- 2020/12/07
CRDT- 2020/12/21 06:06
PHST- 2020/04/21 00:00 [received]
PHST- 2020/06/29 00:00 [accepted]
PHST- 2020/12/21 06:06 [entrez]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2020/12/22 06:01 [medline]
PHST- 2020/12/07 00:00 [pmc-release]
AID - 10.1177_2045894020944117 [pii]
AID - 10.1177/2045894020944117 [doi]
PST - epublish
SO  - Pulm Circ. 2020 Dec 7;10(4):2045894020944117. doi: 10.1177/2045894020944117. 
      eCollection 2020 Oct-Dec.