PMID- 33344653
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20220419
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2020
DP  - 2020
TI  - Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two 
      Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict 
      Type 2 Diabetes Mellitus in Chinese Population.
PG  - 9157430
LID - 10.1155/2020/9157430 [doi]
LID - 9157430
AB  - PURPOSE: To determine whether hypertriglyceridemic waist (HTGW) and high lipid 
      accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus 
      (T2DM), and to investigate the interactions of HTGW and LAP with other components 
      of metabolic syndrome on the risk of T2DM. METHODS: A total of 15,717 eligible 
      participants without baseline T2DM and aged 35 and over were included from a 
      Chinese rural cohort. Cox proportional hazards regression models were used to 
      estimate the association of HTGW and LAP with the incidence of T2DM, and the 
      restricted cubic spline model was used to evaluate the dose-response association. 
      RESULTS: Overall, 867 new T2DM cases were diagnosed after 7.77 years of 
      follow-up. Participants with HTGW had a higher hazard ratio for T2DM (hazard 
      ratio (HR): 6.249, 95% confidence interval (CI): 5.199-7.511) after adjustment 
      for potential confounders. The risk of incident T2DM was increased with quartiles 
      3 and 4 versus quartile 1 of LAP, and the adjusted HRs (95% CIs) were 2.903 
      (2.226-3.784) and 6.298 (4.911-8.077), respectively. There were additive 
      interactions of HTGW (synergy index (SI): 1.678, 95% CI: 1.358-2.072) and high 
      LAP (SI: 1.701, 95% CI: 1.406-2.059) with increased fasting plasma glucose (FPG) 
      on the risk of T2DM. Additionally, a nonlinear (P nonlinear < 0.001) 
      dose-response association was found between LAP and T2DM. CONCLUSION: The 
      subjects with HTGW and high LAP were at high risk of developing T2DM, and the 
      association between LAP and the risk of T2DM may be nonlinear. Our study further 
      demonstrates additive interactions of HTGW and high LAP with increased FPG on the 
      risk of T2DM.
CI  - Copyright (c) 2020 Minrui Xu et al.
FAU - Xu, Minrui
AU  - Xu M
AUID- ORCID: 0000-0001-9319-4761
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Huang, Mingtao
AU  - Huang M
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
AD  - Center for Global Health, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
AD  - Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and 
      Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, 
      School of Public Health, Nanjing Medical University, Nanjing, China.
AD  - Department of Prenatal Diagnosis, Nanjing Maternity and Child Health Care 
      Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
FAU - Qiang, Deren
AU  - Qiang D
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Gu, Jianxin
AU  - Gu J
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Li, Yong
AU  - Li Y
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Pan, Yingzi
AU  - Pan Y
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Yao, Xingjuan
AU  - Yao X
AD  - Changzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
FAU - Xu, Wenchao
AU  - Xu W
AD  - Changzhou Center for Disease Prevention and Control, Changzhou, Jiangsu, China.
FAU - Tao, Yuan
AU  - Tao Y
AD  - Department of Medical Affairs, The Third Affiliated Hospital of Soochow 
      University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
FAU - Zhou, Yihong
AU  - Zhou Y
AUID- ORCID: 0000-0002-0221-2504
AD  - Wujin District Center for Disease Prevention and Control, Changzhou, Jiangsu, 
      China.
FAU - Ma, Hongxia
AU  - Ma H
AUID- ORCID: 0000-0002-2462-9693
AD  - Department of Epidemiology, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
AD  - Center for Global Health, School of Public Health, Nanjing Medical University, 
      Nanjing, China.
AD  - Department of Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and 
      Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, 
      School of Public Health, Nanjing Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20201202
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/blood/diagnosis/*epidemiology
MH  - Female
MH  - Humans
MH  - Hypertriglyceridemia/blood/*diagnosis/epidemiology
MH  - Incidence
MH  - *Lipid Accumulation Product
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/*diagnosis/epidemiology
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Rural Health
MH  - Triglycerides/*blood
MH  - *Waist Circumference
PMC - PMC7725575
COIS- The authors declare that they have no conflict of interest.
EDAT- 2020/12/22 06:00
MHDA- 2021/10/14 06:00
PMCR- 2020/12/02
CRDT- 2020/12/21 06:09
PHST- 2020/04/09 00:00 [received]
PHST- 2020/08/23 00:00 [revised]
PHST- 2020/11/19 00:00 [accepted]
PHST- 2020/12/21 06:09 [entrez]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2020/12/02 00:00 [pmc-release]
AID - 10.1155/2020/9157430 [doi]
PST - epublish
SO  - J Diabetes Res. 2020 Dec 2;2020:9157430. doi: 10.1155/2020/9157430. eCollection 
      2020.