PMID- 33344656
OWN - NLM
STAT- MEDLINE
DCOM- 20210823
LR  - 20210823
IS  - 2314-7156 (Electronic)
IS  - 2314-8861 (Print)
IS  - 2314-7156 (Linking)
VI  - 2020
DP  - 2020
TI  - Nuclear Alarmin Cytokines in Inflammation.
PG  - 7206451
LID - 10.1155/2020/7206451 [doi]
LID - 7206451
AB  - Pathogen-associated molecular patterns (PAMPs) are some nonspecific and highly 
      conserved molecular structures of exogenous specific microbial pathogens, whose 
      products can be recognized by pattern recognition receptor (PRR) on innate immune 
      cells and induce an inflammatory response. Under physiological stress, activated 
      or damaged cells might release some endogenous proteins that can also bind to PRR 
      and cause a harmful aseptic inflammatory response. These endogenous proteins were 
      named damage-associated molecular patterns (DAMPs) or alarmins. Indeed, alarmins 
      can also play a beneficial role in the tissue repair in certain environments. 
      Besides, some alarmin cytokines have been reported to have both nuclear and 
      extracellular effects. This group of proteins includes high-mobility group box-1 
      protein (HMGB1), interleukin (IL)-33, IL-1alpha, IL-1F7b, and IL-16. In this article, 
      we review the involvement of nuclear alarmins such as HMGB1, IL-33, and IL-1alpha 
      under physiological state or stress state and suggest a novel activity of these 
      molecules as central initiators in the development of sterile inflammation.
CI  - Copyright (c) 2020 Lili Jiang et al.
FAU - Jiang, Lili
AU  - Jiang L
AD  - Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's 
      Hospital Affiliated to Nanchang University, Nanchang, China.
FAU - Shao, Yijia
AU  - Shao Y
AD  - Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's 
      Hospital Affiliated to Nanchang University, Nanchang, China.
FAU - Tian, Yao
AU  - Tian Y
AD  - Department of Rheumatology and Clinical Immunology, Jiangxi Provincial People's 
      Hospital Affiliated to Nanchang University, Nanchang, China.
FAU - Ouyang, Changsheng
AU  - Ouyang C
AUID- ORCID: 0000-0002-0232-5576
AD  - Department of Cardiology, Jiangxi Provincial People's Hospital Affiliated to 
      Nanchang University, Nanchang, China.
FAU - Wang, Xiaohua
AU  - Wang X
AUID- ORCID: 0000-0002-9828-6718
AD  - Geriatric Medical Center, Jiangxi Provincial People's Hospital Affiliated to 
      Nanchang University, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201204
PL  - Egypt
TA  - J Immunol Res
JT  - Journal of immunology research
JID - 101627166
RN  - 0 (Alarmins)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Alarmins/*metabolism
MH  - Animals
MH  - Biomarkers
MH  - Cell Nucleus/metabolism
MH  - Cytokines/*metabolism
MH  - *Disease Susceptibility
MH  - HMGB1 Protein/metabolism
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Inflammation/*etiology/*metabolism/pathology
MH  - Inflammation Mediators/metabolism
PMC - PMC7732391
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2020/12/22 06:00
MHDA- 2021/08/24 06:00
PMCR- 2020/12/04
CRDT- 2020/12/21 06:09
PHST- 2020/07/24 00:00 [received]
PHST- 2020/10/25 00:00 [revised]
PHST- 2020/10/29 00:00 [accepted]
PHST- 2020/12/21 06:09 [entrez]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2021/08/24 06:00 [medline]
PHST- 2020/12/04 00:00 [pmc-release]
AID - 10.1155/2020/7206451 [doi]
PST - epublish
SO  - J Immunol Res. 2020 Dec 4;2020:7206451. doi: 10.1155/2020/7206451. eCollection 
      2020.