PMID- 33345897
OWN - NLM
STAT- MEDLINE
DCOM- 20210421
LR  - 20210421
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 194
DP  - 2021 Mar
TI  - Associations of dermal diethyl phthalate level with changes in lung function test 
      value mediated by absolute eosinophil count: A panel study of adults in southern 
      Taiwan.
PG  - 110613
LID - S0013-9351(20)31510-3 [pii]
LID - 10.1016/j.envres.2020.110613 [doi]
AB  - Phthalate concentrations in indoor and outdoor dust are associated with 
      respiratory disease. Both immunoglobulin E (IgE) and eosinophil count are 
      associated with airway inflammation from exposure to environmental allergens. 
      Dermal phthalate level can be used as a matrix for assessing personal exposure 
      through direct absorption from the air, particle deposition, or contact with 
      contaminated products. However, the association between dermal phthalate level 
      and changes in lung function test values, as mediated by immunological response, 
      remains unclear. In total, 237 adults in southern Taiwan were recruited. 
      Spirometry measurements (in L) of forced expiratory volume in 1 s (FEV1) and 
      forced vital capacity (FVC) were taken on visits 1 (2016-2018) and 2 (2019). 
      Dermal phthalate level, absolute eosinophil count, and IgE level were recorded on 
      visit 1. Mean changes in FVC and FEV1 decrease pear year, as determined through 
      pairwise comparisons, were significant ((diff)FVC(per year): -0.46, 95% CI: 
      -0.51, -0.41; p < 0.001; (diff)FEV1(per year): -0.37, 95% confidence interval 
      [CI]: -0.41, -0.34; p < 0.001). For FEV1 decrease, log-unit increases in dermal 
      diethyl phthalate (DEP) were positively associated with (diff)FEV1(per year) 
      (beta = 0.096; 95% CI: 0.042, 0.150; p = 0.001) and negatively associated with 
      absolute eosinophil count (beta= -0.201; 95% CI: -0.380, -0.023; p= 0.027). Log-unit 
      increases in absolute eosinophil count were negatively associated with 
      (diff)FEV1(per year) (beta= -0.109; 95% CI: -0.150, -0.068; p < 0.001). Absolute 
      eosinophil count mediated 19.70% of the association between dermal DEP level and 
      (diff)FEV1(per year). For FVC decrease, log-unit increases in dermal DEP were 
      positively associated with (diff)FVC(per year) (beta = 0.095; 95% CI: 0.035, 0.155; 
      p = 0.002) and negatively associated with absolute eosinophil count (beta = -0.243; 
      95% CI: -0.427, -0.060; p = 0.010). Log-unit increases in absolute eosinophil 
      count were negatively associated with (diff)FVC(per year) (beta= -0.122; 95% CI: 
      -0.168, -0.076; p < 0.001). Absolute eosinophil count mediated 29.98% of the 
      association between dermal DEP level and (diff)FVC(per year). The results suggest 
      that dermal DEP level is positively associated with changes in lung function test 
      values and is mediated by absolute eosinophil count.
CI  - Copyright (c) 2020 Elsevier Inc. All rights reserved.
FAU - Wang, Chih-Wen
AU  - Wang CW
AD  - Division of Hepatobiliary, Department of Internal Medicine, Kaohsiung Medical 
      University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department 
      of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan; Center for Cancer Research, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Wu, Da-Wei
AU  - Wu DW
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan; Division of Pulmonary and Critical Care 
      Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Chen, Szu-Chia
AU  - Chen SC
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan; Research Center for Environmental 
      Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of 
      Nephrology, Department of Internal Medicine, Kaohsiung Medical University 
      Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: 
      scarchenone@yahoo.com.tw.
FAU - Chen, Huang-Chi
AU  - Chen HC
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan; Division of Pulmonary and Critical Care 
      Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, 
      Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Lin, Hung-Hsun
AU  - Lin HH
AD  - Department of Laboratory Technology, Kaohsiung Municipal Siaogang Hospital, 
      Kaohsiung, Taiwan.
FAU - Su, Hung
AU  - Su H
AD  - Department of Chemistry, National Sun Yat-Sen University Kaohsiung, Taiwan.
FAU - Shiea, Jen-Taie
AU  - Shiea JT
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 
      Kaohsiung, Taiwan; Department of Chemistry, National Sun Yat-Sen University 
      Kaohsiung, Taiwan; Department of Medicinal and Applied Chemistry, Kaohsiung 
      Medical University, Kaohsiung, Taiwan.
FAU - Lin, Wen-Yi
AU  - Lin WY
AD  - Department of Occupational Medicine, Health Management Center, Kaohsiung 
      Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung City, 
      Taiwan.
FAU - Hung, Chih-Hsing
AU  - Hung CH
AD  - Division of Pulmonary and Critical Care Medicine, Department of Internal 
      Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, 
      Kaohsiung, Taiwan; Department of Pediatrics, Kaohsiung Medical University 
      Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of 
      Pediatrics, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, 
      Kaohsiung, Taiwan. Electronic address: pedhung@gmail.com.
FAU - Kuo, Chao-Hung
AU  - Kuo CH
AD  - Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 
      Medical University, Kaohsiung, Taiwan; Division of Gastroenterology, Department 
      of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20201224
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Phthalic Acids)
RN  - UF064M00AF (diethyl phthalate)
SB  - IM
MH  - *Eosinophils
MH  - Forced Expiratory Volume
MH  - *Lung
MH  - Phthalic Acids
MH  - Respiratory Function Tests
MH  - Taiwan
MH  - Vital Capacity
OTO - NOTNLM
OT  - Absolute eosinophil count
OT  - Dermal phthalate
OT  - Diethyl phthalate
OT  - Forced expiratory volume in 1 s
OT  - Forced vital capacity
EDAT- 2020/12/22 06:00
MHDA- 2021/04/22 06:00
CRDT- 2020/12/21 08:44
PHST- 2020/09/01 00:00 [received]
PHST- 2020/11/27 00:00 [revised]
PHST- 2020/12/05 00:00 [accepted]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2021/04/22 06:00 [medline]
PHST- 2020/12/21 08:44 [entrez]
AID - S0013-9351(20)31510-3 [pii]
AID - 10.1016/j.envres.2020.110613 [doi]
PST - ppublish
SO  - Environ Res. 2021 Mar;194:110613. doi: 10.1016/j.envres.2020.110613. Epub 2020 
      Dec 24.