PMID- 33346480
OWN - NLM
STAT- MEDLINE
DCOM- 20201222
LR  - 20221207
IS  - 0040-3660 (Print)
IS  - 0040-3660 (Linking)
VI  - 92
IP  - 10
DP  - 2020 Nov 24
TI  - [The pharmacogenetics of hypoglycemia and the glycemic variability at the 
      patients ith type 2 diabetes mellitus].
PG  - 54-62
LID - 10.26442/00403660.2020.10.000530 [doi]
AB  - AIM: To investigate the link between the hypoglycemia (registrated accurately by 
      the professional Continuous Glucose Monitoring CGM; severe hypoglycemia at home) 
      and the hetero-/homozygote carriage of single nucleotide polymorphisms (SNP) of 
      cytochrome systems geneCYP2C9(rs1799853CYP2C9*2 small i, Cyrillicrs1057910CYP2C9*3) at the 
      patients with Type 2 Diabetes Mellitus (T2DM) used sulphonylurea (SU). MATERIALS 
      AND METHODS: In Study Case-Control 120 T2DM-SU-patients genotyped by SNPs of 
      geneCYP2C9(using PCR-RT) had been done the professional CGM (System iPro2, 
      Medtronic) recorded Time in Range of Hypoglycemia (TIR-HYPO), level of Minimal 
      CGM-hypoglycemia (MinGl) and standard CGM-parameters of Glycemic Variability. 
      Severe hypoglycemia at home was recorded from visit to visit. The odds ratio (OR) 
      of metabolic disturbances had been assessed for carriage SNPs in comparison with 
      wide alleles. RESULTS: The Study established that carriage of 
      SNPsrs1799853andrs1057910geneCYP2C9at T2DM-SU-patients associated with rising of 
      Glycemic Variability and frequency of CGM-hypoglycemia (MinGl decreasing, 
      increasing of TIR-HYPO and number of Glycemia Excursion 4 mmol/L/h), as well as 
      increasing severe hypoglycemia at home (p0.05). Thus, OR at the carriage 
      ofrs1799853andrs1057910respectively equaled: for CGM-hypoglycemia 7.78 
      (3.0220.01) and 5.80 (0.23145.87); number of Glycemia Excursion 4 mmol/L/h 5.76 
      (2.2914.43) and 4.44 (1.4313.76); MinGl3.9 mmol/L 4.39 (1.7910.75) and 6.26 
      (1.8421.30); CV40% (vs30%) 3.63 (1.0412.62) and 15.22 (0.59393.94);p0.05. 
      CONCLUSION: At the real clinical practice the assessment of carriage of SNPs of 
      geneCYP2C9before inclusion of SU to glucose-lowering scheme of T2DM-therapy it 
      necessary to carry out for the detecting patients with a higher risk of 
      hypoglycemia and rising of Glycemic Variability.
FAU - Chernikova, N A
AU  - Chernikova NA
AUID- ORCID: 0000-0002-0562-8396
AD  - Russian Medical Academy of Continuous Professional Education.
FAU - Kamynina, L L
AU  - Kamynina LL
AUID- ORCID: 0000-0003-1217-545X
AD  - Russian Medical Academy of Continuous Professional Education.
FAU - Ametov, A S
AU  - Ametov AS
AUID- ORCID: 0000-0002-7936-7619
AD  - Russian Medical Academy of Continuous Professional Education.
FAU - Sychev, D A
AU  - Sychev DA
AUID- ORCID: 0000-0002-4496-3680
AD  - Russian Medical Academy of Continuous Professional Education.
FAU - Grishina, E A
AU  - Grishina EA
AUID- ORCID: 0000-0002-5621-8266
AD  - Russian Medical Academy of Continuous Professional Education.
FAU - Ryzhikova, K A
AU  - Ryzhikova KA
AUID- ORCID: 0000-0003-3505-8520
AD  - Russian Medical Academy of Continuous Professional Education.
LA  - rus
PT  - Journal Article
DEP - 20201124
PL  - Russia (Federation)
TA  - Ter Arkh
JT  - Terapevticheskii arkhiv
JID - 2984818R
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Blood Glucose/metabolism
MH  - Blood Glucose Self-Monitoring
MH  - *Diabetes Mellitus, Type 2/drug therapy/genetics
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - *Hypoglycemia/chemically induced/genetics
MH  - Hypoglycemic Agents/*adverse effects/therapeutic use
MH  - Pharmacogenetics
OTO - NOTNLM
OT  - CGM (Continuous Glucose Monitoring)
OT  - CYP2C9
OT  - SNP (single nucleotide polymorphism)
OT  - genetics
OT  - glycemic variability
OT  - hypoglycemia
OT  - pharmacogenetics
OT  - type 2 diabetes mellitus
EDAT- 2020/12/22 06:00
MHDA- 2020/12/23 06:00
CRDT- 2020/12/21 08:47
PHST- 2020/11/23 00:00 [received]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2020/12/21 08:47 [entrez]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2020/12/23 06:00 [medline]
AID - 10.26442/00403660.2020.10.000530 [doi]
PST - epublish
SO  - Ter Arkh. 2020 Nov 24;92(10):54-62. doi: 10.26442/00403660.2020.10.000530.