PMID- 33347992
OWN - NLM
STAT- MEDLINE
DCOM- 20210326
LR  - 20210326
IS  - 1872-9649 (Electronic)
IS  - 1568-1637 (Linking)
VI  - 66
DP  - 2021 Mar
TI  - Recent advances in the field of caloric restriction mimetics and anti-aging 
      molecules.
PG  - 101240
LID - S1568-1637(20)30375-5 [pii]
LID - 10.1016/j.arr.2020.101240 [doi]
AB  - Caloric restriction (CR) mimetics are molecules that produce beneficial effects 
      on health and longevity in model organisms and humans, without the challenges of 
      maintaining a CR diet. Conventional CR mimetics such as metformin, rapamycin and 
      spermidine activate autophagy, leading to recycling of cellular components and 
      improvement of physiological function. We review here novel CR mimetics and 
      anti-aging compounds, such as 4,4'-dimethoxychalcone, fungal polysaccharides, 
      inorganic nitrate, and trientine, highlighting their possible molecular targets 
      and mechanisms of action. The activity of these compounds can be understood 
      within the context of hormesis, a biphasic dose response that involves beneficial 
      effects at low or moderate doses and toxic effects at high doses. The concept of 
      hormesis has widespread implications for the identification of CR mimetics in 
      experimental assays, testing in clinical trials, and use in healthy humans. We 
      also discuss the promises and limitations of CR mimetics and anti-aging molecules 
      for delaying aging and treating chronic diseases.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Martel, Jan
AU  - Martel J
AD  - Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, 
      Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan.
FAU - Chang, Shih-Hsin
AU  - Chang SH
AD  - Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, 
      Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan.
FAU - Wu, Cheng-Yeu
AU  - Wu CY
AD  - Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, 
      Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan; Research Center of Bacterial Pathogenesis, Chang Gung 
      University, Taoyuan, Taiwan.
FAU - Peng, Hsin-Hsin
AU  - Peng HH
AD  - Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, 
      Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan; Laboratory Animal Center, Chang Gung Memorial Hospital at 
      Linkou, Taoyuan, Taiwan.
FAU - Hwang, Tsong-Long
AU  - Hwang TL
AD  - Graduate Institute of Natural Products, College of Medicine, Chang Gung 
      University, Taoyuan, Taiwan; Research Center for Chinese Herbal Medicine, College 
      of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, 
      Taiwan; Graduate Institute of Health Industry Technology, College of Human 
      Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; 
      Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
FAU - Ko, Yun-Fei
AU  - Ko YF
AD  - Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan; Biochemical Engineering Research Center, Ming Chi University of 
      Technology, New Taipei City, Taiwan; Chang Gung Biotechnology Corporation, 
      Taipei, Taiwan.
FAU - Young, John D
AU  - Young JD
AD  - Chang Gung Biotechnology Corporation, Taipei, Taiwan.
FAU - Ojcius, David M
AU  - Ojcius DM
AD  - Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, 
      Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, 
      Taoyuan, Taiwan; Department of Biomedical Sciences, University of the Pacific, 
      Arthur Dugoni School of Dentistry, San Francisco, CA, USA. Electronic address: 
      dojcius@pacific.edu.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201224
PL  - England
TA  - Ageing Res Rev
JT  - Ageing research reviews
JID - 101128963
SB  - IM
MH  - *Aging
MH  - Autophagy
MH  - *Caloric Restriction
MH  - Hormesis
MH  - Humans
MH  - Longevity
OTO - NOTNLM
OT  - Aging
OT  - Autophagy
OT  - Hormesis
OT  - Phytochemicals
OT  - Polysaccharides
EDAT- 2020/12/22 06:00
MHDA- 2021/03/27 06:00
CRDT- 2020/12/21 20:10
PHST- 2020/10/04 00:00 [received]
PHST- 2020/11/17 00:00 [revised]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2020/12/22 06:00 [pubmed]
PHST- 2021/03/27 06:00 [medline]
PHST- 2020/12/21 20:10 [entrez]
AID - S1568-1637(20)30375-5 [pii]
AID - 10.1016/j.arr.2020.101240 [doi]
PST - ppublish
SO  - Ageing Res Rev. 2021 Mar;66:101240. doi: 10.1016/j.arr.2020.101240. Epub 2020 Dec 
      24.