PMID- 33350212
OWN - NLM
STAT- MEDLINE
DCOM- 20201223
LR  - 20201223
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 45
IP  - 22
DP  - 2020 Nov
TI  - [Preparation and quality evaluation of orodispersible film containing ginkgolide 
      B novel nanosuspension lyophilized powder].
PG  - 5504-5510
LID - 10.19540/j.cnki.cjcmm.20200819.306 [doi]
AB  - To prepare a new dosage form that can improve the drug loading of the 
      film--ginkgolide B nanosuspension lyophilized powder orodispersible 
      film(GB-NS-LP-ODF) and to evaluate its quality. Firstly, ginkgolide B 
      nanosuspension(GB-NS) was prepared by media milling method, and then ginkgolide B 
      nanosuspension lyophilized powder(GB-NS-LP) was prepared with freeze-drying 
      method. The mannitol was used as lyoprotectant and its dosage was also 
      investigated. GB-NS-LP-ODF was prepared by solvent casting method and its 
      formulation was screened by single factor test method and optimized by orthogonal 
      test. The appearance, mechanical properties, content uniformity and in vitro 
      dissolution of the optimized GB-NS-LP-ODF were investigated. The particle size of 
      prepared GB-NS was about 201 nm, and the optimal dosage of mannitol was 8%. 
      According to the optimal formula, the GB-NS-LP-ODF was prepared with GB-NS-LP 
      35.6%, PVA 0588 49.4%, PEG 400 10.7% and CMS-Na 4.3%, and completely 
      disintegrated in about 30 s, and the particle size of reconstituted GB 
      nanoparticles from ODF was about 210 nm. The film with smooth appearance and good 
      mechanical properties was stable within 30 days and the content uniformity(A+2.2 
      S<15) conformed to the regulations. Scanning electron microscope(SEM) showed 
      that GB-NS-LP-ODFs were evenly distributed and the particle size was about 200 
      nm. X-rays diffraction(XRD) showed that its crystallinity was significantly lower 
      than that of GB raw drug and GB-ODF. The results of in vitro release test showed 
      that the drug film was completely dissoluted within 10 minutes. These results 
      indicated that nanosuspension lyophilized powder was prepared by freeze drying of 
      nanosuspensions, and then loaded into the orodispersible film to effectively 
      increase the drug loading of the ODF and have broad application prospects.
FAU - Jing, Wang
AU  - Jing W
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 
      611137, China Department of Pharmacy,Air Force Medical Center, PLA Beijing 
      100142, China.
FAU - Jun-Jun, Zhu
AU  - Jun-Jun Z
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 
      611137, China Department of Pharmacy,Air Force Medical Center, PLA Beijing 
      100142, China.
FAU - Bao-de, Shen
AU  - Bao-de S
AD  - Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
FAU - Ting, Zhang
AU  - Ting Z
AD  - Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
FAU - Bo, Dai
AU  - Bo D
AD  - Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
FAU - Ya-Ning, Zhu
AU  - Ya-Ning Z
AD  - College of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 
      611137, China.
FAU - Hai-Long, Yuan
AU  - Hai-Long Y
AD  - Department of Pharmacy,Air Force Medical Center, PLA Beijing 100142, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Ginkgolides)
RN  - 0 (Lactones)
RN  - 0 (Powders)
RN  - 0 (Suspensions)
RN  - DF149B9460 (ginkgolide B)
SB  - IM
MH  - Ginkgolides
MH  - *Lactones
MH  - *Nanoparticles
MH  - Particle Size
MH  - Powders
MH  - Solubility
MH  - Suspensions
OTO - NOTNLM
OT  - cumulative dissolution
OT  - freezedrying
OT  - ginkgolide B
OT  - nanosuspension
OT  - orodispersible film
OT  - quality evaluation
EDAT- 2020/12/23 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/12/22 05:52
PHST- 2020/12/22 05:52 [entrez]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20200819.306 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2020 Nov;45(22):5504-5510. doi: 
      10.19540/j.cnki.cjcmm.20200819.306.