PMID- 33350250
OWN - NLM
STAT- MEDLINE
DCOM- 20201223
LR  - 20211204
IS  - 1001-5302 (Print)
IS  - 1001-5302 (Linking)
VI  - 45
IP  - 20
DP  - 2020 Oct
TI  - [Molecular regulatory mechanisms of hypoxia-inducible factor and interventional 
      effect of Chinese herbal medicine].
PG  - 4805-4811
LID - 10.19540/j.cnki.cjcmm.20200630.602 [doi]
AB  - Hypoxia-inducible factors(HIFs)are the key transcription factors that sense and 
      regulate cellular oxygen concentration in vivo. HIF-1 is composed of 2 subunits,alpha 
      and beta,in which,the molecular regulatory mechanism of HIF-1alpha involves the main 
      processes of its degradation and activation. The degradation of HIF-1alpha is 
      regulated by oxygen-dependent pathways,including "von hippel-lindau 
      protein(pVHL)-dependent pathway" and "pVHL-independent pathway". 
      The activation of HIF-1alpha is regulated by oxygen-independent pathways,including 
      mammalian target of rapamycin(mTOR)/eukaryotic initiation factor 4 E-binding 
      protein 1(4 EBP1)/HIF-1alpha pathway,phosphatidylinositol 3-kinase(PI3 
      K)/proteirrserinc-threonine kinases(Akt)/HIF-1alpha pathway and silent information 
      regulator1(Sirt1)/HIF-1alpha pathway. In recent years,based on the molecular 
      regulatory mechanism of HIFs,Roxadustat,a new drug for the treatment of renal 
      anemia has been developed. Besides, some macromolecular substances with similar 
      pharmacological effect to HIFs have been found in the extracts from Chinese 
      herbal medicine(CHM),such as emodin,notoginseng triterpenes,honokiol and 
      clematichinenoside. These natural macromolecular substances play the regulatory 
      roles in inflammatory response,epigenetic modification and auto-phagy. It is 
      worth noting that,for common hypoxic-related diseases including diabetic kidney 
      disease,HIFs-mediated "pyroptosis" may be a new target of CHMs for 
      clearing dampness and heat and its representative classical prescriptions(Ermiao 
      Pills)in treating inflammatory injury in cells and tissues.
FAU - Bu-Hui, Liu
AU  - Bu-Hui L
AD  - Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine 
      Nanjing 210029,China Department of Traditional Chinese Medicine,Nanjing Drum 
      Tower Hospital Clinical College of Traditional Chinese and Western 
      Medicine,Nanjing University of Chinese Medicine Nanjing 210008,China.
FAU - Mei-Zi, Wang
AU  - Mei-Zi W
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine,Nanjing University of Chinese 
      Medicine Nanjing 210008,China.
FAU - Wei, Sun
AU  - Wei S
AD  - Nephrology Division,Affiliated Hospital of Nanjing University of Chinese Medicine 
      Nanjing 210029,China.
FAU - Yi-Gang, Wan
AU  - Yi-Gang W
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China.
FAU - Wei, W U
AU  - Wei WU
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China.
FAU - Qi-Jun, Fang
AU  - Qi-Jun F
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine,Nanjing University of Chinese 
      Medicine Nanjing 210008,China.
FAU - Wen-Wen, Wang
AU  - Wen-Wen W
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine,Nanjing University of Chinese 
      Medicine Nanjing 210008,China.
FAU - Hong-Yun, Yee
AU  - Hong-Yun Y
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine,Nanjing University of Chinese 
      Medicine Nanjing 210008,China.
FAU - Can-Can, Yuan
AU  - Can-Can Y
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital Clinical 
      College of Traditional Chinese and Western Medicine,Nanjing University of Chinese 
      Medicine Nanjing 210008,China.
FAU - Ying-Lu, Liu
AU  - Ying-Lu L
AD  - Department of Traditional Chinese Medicine,Nanjing Drum Tower Hospital,The 
      Affiliated Hospital of Nanjing University Medical School Nanjing 210008,China.
FAU - Yue, T U
AU  - Yue TU
AD  - Department of Traditional Chinese Medicine Health Preservation,Acupuncture and 
      Moxibustion and Massage College.Health Preservation and Rehabilitation 
      College,Nanjing University of Chinese Medicine Nanjing 210023,China.
FAU - Fee-Lan, Chong
AU  - Fee-Lan C
AD  - The School of Pharmacy,Management and Science University Shah Alam 
      40100,Malaysia.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Yao Za Zhi
JT  - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese 
      materia medica
JID - 8913656
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
SB  - IM
MH  - *Drugs, Chinese Herbal/pharmacology
MH  - Humans
MH  - Hypoxia
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics
MH  - Protein Serine-Threonine Kinases
MH  - Transcription Factors
OTO - NOTNLM
OT  - Chinese herbal medicine
OT  - hypoxia-inducible factors
OT  - molecular mechanism
OT  - pyroptosis
OT  - signaling pathway
EDAT- 2020/12/23 06:00
MHDA- 2020/12/29 06:00
CRDT- 2020/12/22 05:52
PHST- 2020/12/22 05:52 [entrez]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2020/12/29 06:00 [medline]
AID - 10.19540/j.cnki.cjcmm.20200630.602 [doi]
PST - ppublish
SO  - Zhongguo Zhong Yao Za Zhi. 2020 Oct;45(20):4805-4811. doi: 
      10.19540/j.cnki.cjcmm.20200630.602.