PMID- 33350540
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231129
IS  - 1099-1573 (Electronic)
IS  - 0951-418X (Linking)
VI  - 35
IP  - 5
DP  - 2021 May
TI  - The effect of barberry (Berberis vulgaris) consumption on flow-mediated dilation 
      and inflammatory biomarkers in patients with hypertension: A randomized 
      controlled trial.
PG  - 2607-2615
LID - 10.1002/ptr.7000 [doi]
AB  - Hypertension is considered as an important cardiovascular risk factor and 
      evidence suggests that hypertension and endothelial dysfunction reinforce each 
      other. Polyphenol-rich foods, such as barberry can reduce the risk of 
      cardiovascular disease. Our aim was to investigate the effects of barberry 
      consumption on vascular function and inflammatory markers in hypertensive 
      subject. In this randomized controlled parallel trial, 84 hypertensive subjects 
      of both genders (aged 54.06 +/- 10.19 years; body mass index 28.02 +/- 2.18 kg/m(2) ) 
      were randomly allocated to consume barberry (10 g/day dried barberry) or placebo 
      for 8 weeks. Before and after the intervention, changes in brachial flow-mediated 
      dilation (FMD) and plasma macrophage/monocyte chemo-attractant protein-1 (MCP-1), 
      vascular cellular adhesion molecule-1, and intracellular adhesion molecule-1 
      (ICAM-1) were measured. An intention-to-treat analysis was performed. Compared to 
      placebo (n = 42), barberry consumption (n = 42) improved FMD (B [95% CI] was 
      6.54% [4.39, 8.70]; p < .001) and decreased plasma ICAM-1 (B [95% CI] was 
      -1.61 ng/ml [-2.74, -0.48]; p = .006). MCP-1 was significantly lower in the 
      barberry group compared with the placebo group (B [95% CI] was -37.62 pg/ml 
      [-72.07, -3.17]; p = .033). Our results indicate that barberry consumption 
      improves FMD and has a beneficial effect on plasma ICAM-1 and MCP-1 in 
      hypertensive patients. This trial was registered at the Iranian Registry of 
      Clinical Trial (IRCT) with number IRCT20160702028742N8.
CI  - (c) 2020 John Wiley & Sons, Ltd.
FAU - Emamat, Hadi
AU  - Emamat H
AUID- ORCID: 0000-0002-8562-9136
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, National Nutrition and Food Technology Research Institute, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Asadian, Sanaz
AU  - Asadian S
AD  - Department of Radiology, Shahid Rajaie Cardiovascular, Medical & Research Center, 
      Tehran, Iran.
FAU - Zahedmehr, Ali
AU  - Zahedmehr A
AD  - Cardiovascular Intervention Research Center, Shahid Rajaei Cardiovascular, 
      Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
FAU - Ghanavati, Matin
AU  - Ghanavati M
AUID- ORCID: 0000-0001-7447-3845
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, National Nutrition and Food Technology Research Institute, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Nasrollahzadeh, Javad
AU  - Nasrollahzadeh J
AUID- ORCID: 0000-0002-9133-1870
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and 
      Food Technology, National Nutrition and Food Technology Research Institute, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20201222
PL  - England
TA  - Phytother Res
JT  - Phytotherapy research : PTR
JID - 8904486
SB  - IM
OTO - NOTNLM
OT  - Berberis vulgaris
OT  - FMD
OT  - barberry
OT  - flow-mediated dilation
OT  - hypertension
OT  - inflammation
EDAT- 2020/12/23 06:00
MHDA- 2020/12/23 06:01
CRDT- 2020/12/22 08:46
PHST- 2020/11/05 00:00 [revised]
PHST- 2020/08/27 00:00 [received]
PHST- 2020/12/13 00:00 [accepted]
PHST- 2020/12/23 06:01 [medline]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2020/12/22 08:46 [entrez]
AID - 10.1002/ptr.7000 [doi]
PST - ppublish
SO  - Phytother Res. 2021 May;35(5):2607-2615. doi: 10.1002/ptr.7000. Epub 2020 Dec 22.