PMID- 33350780
OWN - NLM
STAT- MEDLINE
DCOM- 20210115
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 52
DP  - 2020 Dec 24
TI  - The association between age and adverse events due to biologic disease-modifying 
      antirheumatic drugs in patients with rheumatoid arthritis: A retrospective cohort 
      study.
PG  - e23861
LID - 10.1097/MD.0000000000023861 [doi]
LID - e23861
AB  - We examined whether the age of patients with rheumatoid arthritis was associated 
      with adverse events (AEs) caused by biologic disease-modifying antirheumatic 
      drugs (bDMARDs).Patients with rheumatoid arthritis using bDMARDs from Showa 
      University Hospital, Showa University Northern Yokohama Hospital, and Showa 
      University Koto Toyosu Hospital from January 2005 to December 2017 were eligible 
      for this retrospective cohort study. The maximum observation period was 
      determined to be 1 year. Outcomes in patients older and younger than 75 years 
      were compared. The primary outcome was the rate of drug discontinuation because 
      of AEs caused by bDMARDs. Univariate and multivariate analyses were performed 
      using Pearson's chi-squared test and logistic regression analysis, respectively.A 
      total of 416 patients were enrolled; median (interquartile range [IQR]): 60.0 
      (44.3 - 71.0) years and 84.6% women; patients >/= 75 years were 67/416 (16.1%). The 
      rates of drug discontinuation because of AEs caused by bDMARDs were 10.5% (7/67) 
      in patients 75 years and older and 10.9% (38/349) in those younger than 75 years 
      (relative risk 0.95, 95% confidential interval 0.45-2.24). In logistic regression 
      analysis adjusted for covariates, the rate of drug discontinuation showed no 
      significant difference between the patients >/= 75 years and the those < 75 years 
      (adjusted odds ratio 0.70, 95% confidential interval 0.29-1.75, P = .45).The rate 
      of drug discontinuation because of AEs caused by bDMARDs was not significantly 
      different between patients 75 years and older and patients younger than 75 years.
CI  - Copyright (c) 2020 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Ikari, Yuzo
AU  - Ikari Y
AUID- ORCID: 0000-0002-4091-8882
AD  - Division of Rheumatology, Department of Medicine, Showa University School of 
      Medicine, Tokyo.
FAU - Yajima, Nobuyuki
AU  - Yajima N
AUID- ORCID: 0000-0002-8292-3962
AD  - Division of Rheumatology, Department of Medicine, Showa University School of 
      Medicine, Tokyo.
AD  - Department of Healthcare Epidemiology, School of Public Health in the Graduate 
      School of Medicine, Kyoto University, Kyoto.
AD  - Center for Innovative Research for Communities and Clinical Excellence, Fukushima 
      Medical University, Fukushima, Japan.
FAU - Miwa, Yusuke
AU  - Miwa Y
AUID- ORCID: 0000-0001-5956-7974
AD  - Division of Rheumatology, Department of Medicine, Showa University School of 
      Medicine, Tokyo.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Biological Products)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Antirheumatic Agents/administration & dosage/*adverse effects
MH  - *Arthritis, Rheumatoid/drug therapy/epidemiology
MH  - Biological Products/administration & dosage/*adverse effects
MH  - Cohort Studies
MH  - *Drug-Related Side Effects and Adverse Reactions/diagnosis/epidemiology
MH  - Female
MH  - Humans
MH  - Japan/epidemiology
MH  - Male
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Withholding Treatment/*statistics & numerical data
PMC - PMC7769304
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2020/12/23 06:00
MHDA- 2021/01/16 06:00
PMCR- 2020/12/24
CRDT- 2020/12/22 11:22
PHST- 2020/05/08 00:00 [received]
PHST- 2020/11/21 00:00 [accepted]
PHST- 2020/12/22 11:22 [entrez]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2021/01/16 06:00 [medline]
PHST- 2020/12/24 00:00 [pmc-release]
AID - 00005792-202012240-00062 [pii]
AID - MD-D-20-04182 [pii]
AID - 10.1097/MD.0000000000023861 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Dec 24;99(52):e23861. doi: 
      10.1097/MD.0000000000023861.