PMID- 33350798
OWN - NLM
STAT- MEDLINE
DCOM- 20210115
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 99
IP  - 52
DP  - 2020 Dec 24
TI  - HLA-A *24:02 associated with lamotrigine-induced cutaneous adverse drug reactions: 
      A systematic review and meta-analysis.
PG  - e23929
LID - 10.1097/MD.0000000000023929 [doi]
LID - e23929
AB  - BACKGROUND: Several studies demonstrated a connection between human leukocyte 
      antigen (HLA)-B *1502 and lamotrigine (LTG)-induced cutaneous adverse drug 
      reactions (cADRs). The correlation between the HLA-A *24:02 and LTG-cADRs remains 
      controversial. To examine the associations between HLA-A *24:02 and LTG-cADRs, we 
      conducted a systematic review and meta-analysis. METHODS: We performed a 
      comprehensive search of the literature in several electronic database systems 
      including Cochrane Library, EMBASE and PubMed from inception to January 2020. 
      Review Manager was used to compare the frequencies of HLA-A *24:02 carriers 
      between the subgroups. RESULTS: A total of 5 studies were eligible, including 197 
      LTD-cADRs, 396 LTD-tolerant controls, and 2068 population controls. Compared with 
      the LTG-tolerant controls, there was a statistically significant association 
      between the HLA-A *24:02 allele and LTG-induced cADRs (odds ratios: 1.94, 95% 
      confidence intervals 1.06-3.54; P = .03). Compared with the general population, 
      the relationship between the HLA-A *24:02 genotype and LTG-induced cADRs was 
      statistically significant (summary odds ratios: 2.12, 95% confidence intervals 
      1.04-4.30; P = .04). CONCLUSIONS: HLA-A *24:02 may be a risk factor for LTG-cADRs.
CI  - Copyright (c) 2020 the Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Li, Wanshu
AU  - Li W
AD  - Department of Pharmacy.
FAU - Wang, Jie
AU  - Wang J
AD  - Department of Pharmacy.
FAU - Lin, Hangjuan
AU  - Lin H
AD  - Department of Pharmacy.
FAU - Shen, Gang
AU  - Shen G
AD  - Department of Surgery, Ningbo Municipal Hospital of Traditional Chinese Medicine, 
      Ningbo, Zhejiang, PR China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-A*24:02 antigen)
RN  - 0 (HLA-A24 Antigen)
RN  - U3H27498KS (Lamotrigine)
SB  - IM
MH  - Anticonvulsants/adverse effects/pharmacology
MH  - Drug Eruptions/*genetics
MH  - HLA-A24 Antigen/*genetics
MH  - Humans
MH  - Lamotrigine/*adverse effects/pharmacology
MH  - Pharmacogenomic Variants
MH  - Risk Factors
PMC - PMC7769343
COIS- The authors have no funding and conflicts of interest to disclose.
EDAT- 2020/12/23 06:00
MHDA- 2021/01/16 06:00
PMCR- 2020/12/24
CRDT- 2020/12/22 11:22
PHST- 2020/04/04 00:00 [received]
PHST- 2020/11/27 00:00 [accepted]
PHST- 2020/12/22 11:22 [entrez]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2021/01/16 06:00 [medline]
PHST- 2020/12/24 00:00 [pmc-release]
AID - 00005792-202012240-00080 [pii]
AID - MD-D-20-03074 [pii]
AID - 10.1097/MD.0000000000023929 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2020 Dec 24;99(52):e23929. doi: 
      10.1097/MD.0000000000023929.