PMID- 33351343
OWN - NLM
STAT- MEDLINE
DCOM- 20211014
LR  - 20211014
IS  - 2308-1430 (Electronic)
IS  - 0375-9660 (Linking)
VI  - 66
IP  - 2
DP  - 2020 Aug 30
TI  - [The role of non-coding RNAs in the pathogenesis of multiple endocrine neoplasia 
      syndrome type 1].
PG  - 4-12
LID - 10.14341/probl12413 [doi]
AB  - Changes in the expression of non-coding ribonucleic acids (ncRNAs) take part in 
      the formation of various tumors. Multiple endocrine neoplasia syndrome type 1 
      (MEN1) is a rare autosomal dominant disease caused by mutations of the MEN1 gene 
      encoding the menin protein. This syndrome is characterized by the occurrence of 
      parathyroid tumors, gastroenteropancreatic neuroendocrine tumors, pituitary 
      adenomas, as well as other endocrine and non-endocrine tumors. The pathogenesis 
      of MEN-1 associated tumors due to MEN1 mutations remains unclear. In the absence 
      of mutations of the MEN1 gene in patients with phenotypically similar features, 
      this condition is regarded as a phenocopy of this syndrome. The cause of the 
      combination of several MEN-1-related tumors in these patients remains unknown. 
      The possible cause is that changes in the expression of ncRNAs affect the 
      regulation of signaling pathways in which menin participates and may contribute 
      to the development of MEN-1-related tumors. The identification of even a small 
      number of agents interacting with menin makes a significant contribution to the 
      improvement of knowledge about its pathophysiological influence and ways of 
      developing tumors within the MEN-1 syndrome and its phenocopies.
FAU - Mamedova, Elizaveta O
AU  - Mamedova EO
AD  - Endocrinology Research Centre.
FAU - Dimitrova, Diana A
AU  - Dimitrova DA
AD  - Endocrinology Research Centre.
FAU - Belaya, Zhanna E
AU  - Belaya ZE
AD  - Endocrinology Research Centre.
FAU - Melnichenko, Galina A
AU  - Melnichenko GA
AD  - Endocrinology Research Centre.
LA  - rus
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20200830
PL  - Russia (Federation)
TA  - Probl Endokrinol (Mosk)
JT  - Problemy endokrinologii
JID - 0140673
SB  - IM
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/genetics
MH  - *Neuroendocrine Tumors
MH  - *Pancreatic Neoplasms/genetics
MH  - *Parathyroid Neoplasms/genetics
MH  - *Pituitary Neoplasms/genetics
EDAT- 2020/12/23 06:00
MHDA- 2021/10/15 06:00
CRDT- 2020/12/22 12:42
PHST- 2020/04/29 00:00 [received]
PHST- 2020/06/15 00:00 [accepted]
PHST- 2020/06/02 00:00 [revised]
PHST- 2020/12/22 12:42 [entrez]
PHST- 2020/12/23 06:00 [pubmed]
PHST- 2021/10/15 06:00 [medline]
AID - 10.14341/probl12413 [doi]
PST - epublish
SO  - Probl Endokrinol (Mosk). 2020 Aug 30;66(2):4-12. doi: 10.14341/probl12413.