PMID- 33353083
OWN - NLM
STAT- MEDLINE
DCOM- 20210709
LR  - 20210709
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 9
IP  - 12
DP  - 2020 Dec 18
TI  - Fibronectin and Its Receptors in Hematopoiesis.
LID - 10.3390/cells9122717 [doi]
LID - 2717
AB  - Fibronectin is a ubiquitous extracellular matrix protein that is produced by many 
      cell types in the bone marrow and distributed throughout it. Cells of the stem 
      cell niche produce the various isoforms of this protein. Fibronectin not only 
      provides the cells a scaffold to bind to, but it also modulates their behavior by 
      binding to receptors on the adjacent hematopoietic stem cells and stromal cells. 
      These receptors, which include integrins such as alpha4beta1, alpha9beta1, alpha4beta7, alpha5beta1, alphavbeta3, 
      Toll-like receptor-4 (TLR-4), and CD44, are found on the hematopoietic stem cell. 
      Because the knockout of fibronectin is lethal during embryonal development and 
      because fibronectin is produced by almost all cell types in mammals, the study of 
      its role in hematopoiesis is difficult. Nevertheless, strong and direct evidence 
      exists for its stimulation of myelopoiesis and thrombopoiesis using in vivo 
      models. Other reviewed effects can be deduced from the study of fibronectin 
      receptors, which showed their activation modifies the behavior of hematopoietic 
      stem cells. Erythropoiesis was only stimulated under hemolytic stress, and mostly 
      late stages of lymphocytic differentiation were modulated. Because fibronectin is 
      ubiquitously expressed, these interactions in health and disease need to be taken 
      into account whenever any molecule is evaluated in hematopoiesis.
FAU - Wirth, Franziska
AU  - Wirth F
AD  - Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
FAU - Lubosch, Alexander
AU  - Lubosch A
AD  - Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
FAU - Hamelmann, Stefan
AU  - Hamelmann S
AD  - Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
FAU - Nakchbandi, Inaam A
AU  - Nakchbandi IA
AD  - Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany.
AD  - Max-Planck Institute for Medical Research, 69120 Heidelberg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20201218
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (CD44 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Integrins)
RN  - 0 (Receptors, Fibronectin)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cell Proliferation
MH  - Erythropoiesis
MH  - Fibronectins/*physiology
MH  - *Hematopoiesis
MH  - Hematopoietic Stem Cells/cytology
MH  - Hemolysis
MH  - Humans
MH  - Hyaluronan Receptors/metabolism
MH  - Integrins/metabolism
MH  - Mice
MH  - Myelopoiesis
MH  - Receptors, Fibronectin/*physiology
MH  - Stem Cell Niche
MH  - Stem Cells/cytology
MH  - Thrombopoiesis
MH  - Toll-Like Receptor 4/metabolism
PMC - PMC7765895
OTO - NOTNLM
OT  - adhesion
OT  - fibronectin
OT  - hematopoiesis
OT  - homing
OT  - integrin
OT  - migration
OT  - myelopoiesis
OT  - thrombopoiesis
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2020/12/24 06:00
MHDA- 2021/07/10 06:00
PMCR- 2020/12/18
CRDT- 2020/12/23 01:02
PHST- 2020/11/12 00:00 [received]
PHST- 2020/12/08 00:00 [revised]
PHST- 2020/12/15 00:00 [accepted]
PHST- 2020/12/23 01:02 [entrez]
PHST- 2020/12/24 06:00 [pubmed]
PHST- 2021/07/10 06:00 [medline]
PHST- 2020/12/18 00:00 [pmc-release]
AID - cells9122717 [pii]
AID - cells-09-02717 [pii]
AID - 10.3390/cells9122717 [doi]
PST - epublish
SO  - Cells. 2020 Dec 18;9(12):2717. doi: 10.3390/cells9122717.