PMID- 33353138
OWN - NLM
STAT- MEDLINE
DCOM- 20210209
LR  - 20210209
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 17
IP  - 24
DP  - 2020 Dec 18
TI  - Long-Term Benefits of Tailored Exercise in Severe Sarcoidosis: A Case Report.
LID - 10.3390/ijerph17249512 [doi]
LID - 9512
AB  - BACKGROUND: We studied the effects of a supervised, structured exercise program 
      in a severe sarcoidosis patient. METHODS: After being clinically stable for two 
      years, a 52-year-old woman (stage IV, American Thoracic Society) who originally 
      had irreversible lung fibrosis, pulmonary arterial hypertension (PAH), mild 
      mitral insufficiency, and atrial dilatation, and was candidate for lung 
      transplant, performed a combined high-intensity interval, high load resistance, 
      and inspiratory muscle training for 4.5 years, and was tested (cardiopulmonary 
      exercise testing and dual X-ray absorptiometry) every six months. RESULTS: 
      Cardiorespiratory fitness (CRF) and maximal pulmonary ventilation increased by 
      44% and 60%, respectively. Ventilatory efficiency also improved (decrease in the 
      ventilatory equivalent for oxygen by 32% and 14% at the ventilatory threshold and 
      respiratory compensation point, respectively). She improved New York Heart 
      Association (NYHA) class (from III to II), and cardiac alterations as well as PAH 
      reversed so that she was not in need of lung transplantation anymore. Likewise, 
      she suffered no more episodes of hemoptysis. Bone health was overall maintained 
      despite the post-menopausal status and the corticoid treatment. CONCLUSIONS: A 
      long-term combined exercise intervention safely contributed-at least partly-to 
      improve CRF and NYHA class in a patient with severe sarcoidosis, suggesting a 
      potential coadjuvant effect to attenuate clinical manifestations.
FAU - Herrera-Olivares, Alba M
AU  - Herrera-Olivares AM
AUID- ORCID: 0000-0002-4019-7763
AD  - Faculty of Sport Sciences, Universidad Europea de Madrid, 18670 Madrid, Spain.
FAU - Garcia-Manso, Juan M
AU  - Garcia-Manso JM
AD  - Hospital San Juan de Dios, Santa Cruz de Tenerife, 38009 Canary Islands, Spain.
FAU - Rodriguez-Gomez, Irene
AU  - Rodriguez-Gomez I
AUID- ORCID: 0000-0002-1622-7109
AD  - GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45004 Toledo, 
      Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain.
FAU - Ara, Ignacio
AU  - Ara I
AUID- ORCID: 0000-0002-2854-6684
AD  - GENUD Toledo Research Group, Universidad de Castilla-La Mancha, 45004 Toledo, 
      Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain.
FAU - Lucia, Alejandro
AU  - Lucia A
AD  - Faculty of Sport Sciences, Universidad Europea de Madrid, 18670 Madrid, Spain.
AD  - CIBER of Frailty and Healthy Aging (CIBERFES), 28029 Madrid, Spain.
AD  - Instituto de Investigacion Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
FAU - Santalla, Alfredo
AU  - Santalla A
AUID- ORCID: 0000-0001-9418-0564
AD  - Instituto de Investigacion Hospital 12 de Octubre (imas12), 28041 Madrid, Spain.
AD  - Faculty of Sport Sciences, Universidad Pablo de Olavide, 41013 Seville, Spain.
LA  - eng
PT  - Case Reports
PT  - Research Support, Non-U.S. Gov't
DEP - 20201218
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - *Cardiorespiratory Fitness
MH  - *Exercise
MH  - Exercise Test
MH  - Exercise Tolerance
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - *Sarcoidosis/therapy
PMC - PMC7766182
OTO - NOTNLM
OT  - cardiopulmonary exercise test
OT  - high-intensity interval training
OT  - inspiratory muscle training
OT  - pulmonary fibrosis
COIS- The authors declare no conflict of interests.
EDAT- 2020/12/24 06:00
MHDA- 2021/02/10 06:00
PMCR- 2020/12/01
CRDT- 2020/12/23 01:02
PHST- 2020/10/25 00:00 [received]
PHST- 2020/12/04 00:00 [revised]
PHST- 2020/12/12 00:00 [accepted]
PHST- 2020/12/23 01:02 [entrez]
PHST- 2020/12/24 06:00 [pubmed]
PHST- 2021/02/10 06:00 [medline]
PHST- 2020/12/01 00:00 [pmc-release]
AID - ijerph17249512 [pii]
AID - ijerph-17-09512 [pii]
AID - 10.3390/ijerph17249512 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2020 Dec 18;17(24):9512. doi: 
      10.3390/ijerph17249512.