PMID- 33354208
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 1687-6105 (Print)
IS  - 1687-6113 (Electronic)
IS  - 1687-6113 (Linking)
VI  - 2020
DP  - 2020
TI  - Probiotics in the Management of Atopic Dermatitis for Children: A Case-Based 
      Review.
PG  - 4587459
LID - 10.1155/2020/4587459 [doi]
LID - 4587459
AB  - BACKGROUND: Atopic dermatitis or eczema is one of the most common dermatologic 
      problems, especially in children. Several studies have hypothesized that 
      alteration of gut-colonizing microbes might have induced and conditioned the 
      development of the disease. Thus, modulation of microbial diversity and abundance 
      might help alleviate symptoms and conditions for patients. Given the ability of 
      commensal and symbiotic microorganisms in modulating the immune system, 
      probiotics administration has been studied in previous research in the management 
      of eczema. However, until today, there are conflicting results between studies 
      making inconclusive recommendations towards probiotics supplementation in the 
      management of atopic dermatitis. This case-based review was done to assess and 
      evaluate the therapeutic efficacy of probiotics supplementation in the management 
      of eczema in children. METHOD: An electronic database search was conducted in 
      PubMed-NCBI, Cochrane, EBSCO, ProQuest, and SCOPUS in March 2020. Individual 
      studies and reviews were then gathered for screening using predetermined 
      inclusion and exclusion criteria. The included studies were then critically 
      appraised for their validity and importance. RESULT: A total of 5 studies, all of 
      which were RCTs, were included in this review. Out of all the studies included, 4 
      showed no clinically significant improvements in using probiotics in the 
      management of eczema in children as they did not pass the minimal clinically 
      important difference (MCID) of eczema severity as determined by SCORAD (SCORing 
      Atopic Dermatitis). CONCLUSION: Supplementation of probiotics in the management 
      of eczema in children does not show a clinically relevant difference vs. standard 
      treatment in reducing eczema severity.
CI  - Copyright (c) 2020 Ashila Putri Disamantiaji et al.
FAU - Disamantiaji, Ashila Putri
AU  - Disamantiaji AP
AD  - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
FAU - Izza, Endang Farihatul
AU  - Izza EF
AD  - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
FAU - Soelaeman, Muhamad Faza
AU  - Soelaeman MF
AD  - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
FAU - Sembiring, Tannia
AU  - Sembiring T
AD  - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
FAU - Louisa, Melva
AU  - Louisa M
AUID- ORCID: 0000-0002-9451-0380
AD  - Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas 
      Indonesia, Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201207
PL  - Egypt
TA  - Dermatol Res Pract
JT  - Dermatology research and practice
JID - 101312803
PMC - PMC7737446
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2020/12/24 06:00
MHDA- 2020/12/24 06:01
PMCR- 2020/12/07
CRDT- 2020/12/23 05:49
PHST- 2020/05/20 00:00 [received]
PHST- 2020/11/12 00:00 [revised]
PHST- 2020/11/18 00:00 [accepted]
PHST- 2020/12/23 05:49 [entrez]
PHST- 2020/12/24 06:00 [pubmed]
PHST- 2020/12/24 06:01 [medline]
PHST- 2020/12/07 00:00 [pmc-release]
AID - 10.1155/2020/4587459 [doi]
PST - epublish
SO  - Dermatol Res Pract. 2020 Dec 7;2020:4587459. doi: 10.1155/2020/4587459. 
      eCollection 2020.