PMID- 33354443
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201223
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 12
IP  - 11
DP  - 2020 Nov 16
TI  - Pakistan Following Foot Prints of Developed World in Structural Interventions: 
      Experience of Transcatheter Aortic Valve Implantation Reported First Time.
PG  - e11497
LID - 10.7759/cureus.11497 [doi]
LID - e11497
AB  - Background The aim of this study was to evaluate the safety and efficacy of 
      transcatheter aortic valve implantation (TAVI) program in a Tertiary care 
      hospital in Karachi, Pakistan. Methodology This study was conducted by 
      interventional cardiology department of the National Institute of Cardiovascular 
      Diseases (NICVD), Karachi from July 2015 to February 2020. All patients of severe 
      aortic stenosis (AS) who underwent TAVI were included. Baseline characteristics, 
      in-hospital course and one-month follow-up data were collected. Results This 
      study included 100 consecutive patients with severe AS undergoing TAVI. 
      Sixty-three (63.0%) patients were males and the mean age was 67.38 +/- 10.73 years. 
      Eighty-five (85%) patients were in the New York Heart Association (NYHA) class 
      III-IV. Aortic valve mean gradient was 51.33+/-10.47 mmHg and 50% of patients had 
      bicuspid aortic valves. Core valve was implanted in 86 (86%) and evolute-R aortic 
      valve was implanted in 14 (14%) patients. TAVI was successfully done in 94% of 
      patients. Post-deployment aortic valve mean gradient was 5.33+/-4.13 mmHg. Major 
      vascular access site complications were noted in 14% and atrioventricular (AV) 
      blocks were seen in 22% of cases. There was a significant difference in symptoms 
      of patients before and after the procedure. Overall, eight (8%) patients expired 
      during hospital stay. At one-month follow-up, 76% of patients were found to have 
      no limitation of physical activities. Conclusions Results of this study showed 
      that TAVI is a safe procedure in these high-risk patients and is an alternative 
      to surgery for AS patients in the region.
CI  - Copyright (c) 2020, Ammar et al.
FAU - Ammar, Ali
AU  - Ammar A
AD  - Adult Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
FAU - Hassan Rizvi, Syed N
AU  - Hassan Rizvi SN
AD  - Interventional Cardiology, National Institute of Cardiovascular Diseases, 
      Karachi, PAK.
FAU - Saghir, Tahir
AU  - Saghir T
AD  - Interventional Cardiology, National Institute of Cardiovascular Diseases, 
      Karachi, PAK.
FAU - Khan, Naveedullah
AU  - Khan N
AD  - Interventional Cardiology, National Institute of Cardiovascular Diseases, 
      Karachi, PAK.
FAU - Akhtar, Parveen
AU  - Akhtar P
AD  - Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
FAU - Mengal, Naeem
AU  - Mengal N
AD  - Cardiology/Interventional Cardiology, National Institute of Cardiovascular 
      Diseases, Karachi, PAK.
FAU - Sial, Jawaid A
AU  - Sial JA
AD  - Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
FAU - Qamar, Nadeem
AU  - Qamar N
AD  - Cardiology, National Institute of Cardiovascular Diseases, Karachi, PAK.
LA  - eng
PT  - Journal Article
DEP - 20201116
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC7744204
OTO - NOTNLM
OT  - aortic valve stenosis
OT  - atrioventricular block
OT  - bicuspid aortic valve
OT  - heart valve diseases
OT  - transcatheter aortic valve replacement
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/12/24 06:00
MHDA- 2020/12/24 06:01
PMCR- 2020/11/16
CRDT- 2020/12/23 05:50
PHST- 2020/12/23 05:50 [entrez]
PHST- 2020/12/24 06:00 [pubmed]
PHST- 2020/12/24 06:01 [medline]
PHST- 2020/11/16 00:00 [pmc-release]
AID - 10.7759/cureus.11497 [doi]
PST - epublish
SO  - Cureus. 2020 Nov 16;12(11):e11497. doi: 10.7759/cureus.11497.