PMID- 33354652
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210119
IS  - 2513-9886 (Electronic)
IS  - 2513-9886 (Linking)
VI  - 3
DP  - 2020
TI  - Personality traits in psychosis and psychosis risk linked to TSPO expression: a 
      neuroimmune marker.
PG  - e14
LID - 10.1017/pen.2020.14 [doi]
LID - e14
AB  - Personality has been correlated with differences in cytokine expression, an 
      indicator of peripheral inflammation; however, the associations between 
      personality and central markers of inflammation have never been investigated in 
      vivo in humans. Microglia are the resident macrophages of the central nervous 
      system, and the first responders to tissue damage and brain insult. Microglial 
      activation is associated with elevated expression of translocator protein 18kDa 
      (TSPO), which can be imaged with positron emission tomography (PET) to quantify 
      immune activation in the human brain. This study aimed to investigate the 
      association between personality and TSPO expression across the psychosis 
      spectrum. A total of 61 high-resolution [(18)F]FEPPA PET scans were conducted in 
      28 individuals at clinical high risk (CHR) for psychosis, 19 First-Episode 
      Psychosis (FEP), and 14 healthy volunteers (HVs), and analyzed using a two-tissue 
      compartment model and plasma input function to obtain a total volume of 
      distribution (V(T)) as an index of brain TSPO expression (controlling for the 
      rs6971 TSPO polymorphism). Personality was assessed using the Revised NEO 
      Personality Inventory (NEO-PI-R). We found TSPO expression to be specifically 
      associated with neuroticism. A positive association between TSPO expression and 
      neuroticism was found in HVs, in contrast to a nonsignificant, negative 
      association in CHR and significant negative association in FEP. The 
      TSPO-associated neuroticism trait indicates an unexplored connection between 
      neuroimmune activation and personality that varies across the psychosis spectrum.
CI  - (c) The Author(s) 2020.
FAU - Gerritsen, Cory
AU  - Gerritsen C
AUID- ORCID: 0000-0001-8530-772X
AD  - Forensic Early Intervention Service, Centre for Addiction and Mental Health, 
      Toronto, Ontario, Canada.
FAU - Iyengar, Yajur
AU  - Iyengar Y
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
AD  - School of Interdisciplinary Science, McMaster University, Hamilton, Ontario, 
      Canada.
FAU - DaSilva, Tania
AU  - DaSilva T
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
FAU - Koppel, Alex
AU  - Koppel A
AD  - Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, 
      Ontario, Canada.
FAU - Rusjan, Pablo
AU  - Rusjan P
AD  - Douglas Research Centre, McGill University, Montreal, Quebec, Canada.
FAU - Bagby, R Michael
AU  - Bagby RM
AD  - Department of Psychology, University of Toronto, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Douglas Research Centre, McGill University, Montreal, Quebec, Canada.
LA  - eng
GR  - R01 MH100043/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20201124
PL  - England
TA  - Personal Neurosci
JT  - Personality neuroscience
JID - 101718316
PMC - PMC7737185
OTO - NOTNLM
OT  - Neuroinflammation
OT  - Personality
OT  - Positron Emission Tomography
OT  - Psychosis
OT  - TSPO
EDAT- 2020/12/24 06:00
MHDA- 2020/12/24 06:01
PMCR- 2020/11/24
CRDT- 2020/12/23 05:51
PHST- 2019/10/10 00:00 [received]
PHST- 2020/08/19 00:00 [revised]
PHST- 2020/08/25 00:00 [accepted]
PHST- 2020/12/23 05:51 [entrez]
PHST- 2020/12/24 06:00 [pubmed]
PHST- 2020/12/24 06:01 [medline]
PHST- 2020/11/24 00:00 [pmc-release]
AID - S2513988620000140 [pii]
AID - 10.1017/pen.2020.14 [doi]
PST - epublish
SO  - Personal Neurosci. 2020 Nov 24;3:e14. doi: 10.1017/pen.2020.14. eCollection 2020.