PMID- 33356412
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 35
IP  - 5
DP  - 2021 Sep
TI  - Evaluation of Serum Total Immunoglobulin E, Interleukin-17 and Pentraxin-3 as 
      Biomarkers for Chronic Rhinosinusitis With Nasal Polyposis.
PG  - 640-646
LID - 10.1177/1945892420983787 [doi]
AB  - BACKGROUND: Different biomarkers are detectable in cases of chronic 
      rhinosinusitis with nasal polyposis (CRSwNP) with need for evaluation of their 
      diagnostic and prognostic roles. OBJECTIVE: To assess the serum levels of total 
      IgE, interleukin-17 and Pentraxin-3 in patients with CRSwNP and correlate them 
      with the clinical evaluation using Sino-Nasal Outcome Test (SNOT-22), 
      radiological evaluation using Lund - Mackay (LM) computed tomography scan score, 
      and polyposis recurrence. METHODS: This cross-sectional comparative study was 
      carried out on fifty patients with CRSwNP and twenty-five age and gender matched 
      healthy volunteers as control group. Patients were assessed clinically by SNOT-22 
      and radiologically by LM score. Blood samples of patients and controls were 
      analyzed for serum levels of total immunoglobulin E (IgE), Interleukin-17 (IL-17) 
      and Pentraxin-3 (PTX-3). The correlation between the serum levels of every two 
      markers of the study markers was assessed. The levels of the three biomarkers 
      were correlated with SNOT-22 and LM scores and polyp recurrence with assessment 
      of their sensitivity and specificity to diagnose CRSwNP. RESULTS: This study 
      showed significantly higher values of the three biomarkers in patients group 
      compared with control group (p < 0.001 for all). There were significant positive 
      correlations between the levels of the three markers and SNOT 22 and LM scores 
      (p < 0.001 for all) and with recurrence of polyposis (p < 0.001, p = 0.005 and 
      p = 0.032 respectively). Agreement (sensitivity and specificity) for these 
      markers to diagnose patient group was statistically significant (p < 0.001 for 
      all). There was a significant positive correlation between every two markers of 
      the study markers. CONCLUSION: Serum levels of total IgE, IL-17 and PTX-3 are 
      important biological markers for diagnosis and follow up of cases of CRSwNP with 
      high sensitivity and specificity in detection of such cases. They should be 
      included in the routine laboratory workup for cases of CRSwNP.
FAU - Hussien, Hossam A
AU  - Hussien HA
AD  - Otorhinolaryngology Department, Faculty of Medicine, Menoufia University, Shibin 
      el Kom, Egypt.
FAU - Habieb, Mona S
AU  - Habieb MS
AD  - Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, 
      Menoufia University, Shibin el Kom, Egypt.
FAU - Hamdan, Ahmad M
AU  - Hamdan AM
AUID- ORCID: 0000-0002-5148-2041
AD  - Otorhinolaryngology Department, Faculty of Medicine, Menoufia University, Shibin 
      el Kom, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20201223
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Biomarkers)
RN  - 0 (Interleukin-17)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Biomarkers
MH  - Chronic Disease
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Immunoglobulin E
MH  - Interleukin-17
MH  - *Nasal Polyps/diagnosis
MH  - Neoplasm Recurrence, Local
MH  - *Rhinitis/diagnosis
OTO - NOTNLM
OT  - Lund Mackay score
OT  - Pentraxin-3
OT  - Sinonasal Outcome Test 22
OT  - biomarkers
OT  - chronic rhinosinusitis with nasal polyposis
OT  - immunoglobulin E
OT  - interleukin-17
OT  - polyposis recurrence
OT  - sinusitis
EDAT- 2020/12/29 06:00
MHDA- 2021/09/14 06:00
CRDT- 2020/12/28 10:07
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/12/28 10:07 [entrez]
AID - 10.1177/1945892420983787 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2021 Sep;35(5):640-646. doi: 10.1177/1945892420983787. Epub 
      2020 Dec 23.