PMID- 33356513
OWN - NLM
STAT- MEDLINE
DCOM- 20210930
LR  - 20210930
IS  - 2169-5202 (Electronic)
IS  - 1550-0594 (Linking)
VI  - 52
IP  - 6
DP  - 2021 Nov
TI  - Decreased Gamma Auditory Steady-State Response Is Associated With Impaired 
      Real-World Functioning in Unmedicated Patients at Clinical High Risk for 
      Psychosis.
PG  - 400-405
LID - 10.1177/1550059420982706 [doi]
AB  - AIM: Deficits in synchronous, gamma-frequency neural oscillations may contribute 
      to schizophrenia patients' real-world functional impairment and can be measured 
      electroencephalographically using the auditory steady-state response (ASSR). 
      Gamma ASSR deficits have been reported in schizophrenia patients and individuals 
      at clinical high risk (CHR) for developing psychosis. We hypothesized that, in 
      CHR patients, gamma ASSR would correlate with real-world functioning, consistent 
      with a role for gamma synchrony deficits in functional impairment. METHODS: A 
      total of 35 CHR patients rated on Global Functioning: Social and Role scales had 
      EEG recorded while listening to 1-ms, 93-dB clicks presented at 40 Hz in 500-ms 
      trains, in response to which 40-Hz evoked power and intertrial phase-locking 
      factor (PLF) were measured. RESULTS: In CHR patients, lower 40-Hz PLF correlated 
      with lower social functioning. CONCLUSIONS: Gamma synchrony deficits may be a 
      biomarker of real-world impairment at early stages of the schizophrenia disease 
      trajectory.
FAU - Ahmed, Sarah
AU  - Ahmed S
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Lepock, Jennifer R
AU  - Lepock JR
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
FAU - Mizrahi, Romina
AU  - Mizrahi R
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Bagby, R Michael
AU  - Bagby RM
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Gerritsen, Cory J
AU  - Gerritsen CJ
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
AD  - Graduate Department of Psychological Clinical Science, University of Toronto, 
      Toronto, Ontario, Canada.
FAU - Korostil, Michele
AU  - Korostil M
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
FAU - Light, Gregory A
AU  - Light GA
AD  - Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
FAU - Kiang, Michael
AU  - Kiang M
AUID- ORCID: 0000-0003-1113-9211
AD  - Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
AD  - Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
AD  - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
LA  - eng
PT  - Journal Article
DEP - 20201223
PL  - United States
TA  - Clin EEG Neurosci
JT  - Clinical EEG and neuroscience
JID - 101213033
SB  - IM
MH  - Acoustic Stimulation
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory
MH  - Humans
MH  - *Psychotic Disorders
MH  - *Schizophrenia/diagnosis
OTO - NOTNLM
OT  - cortical synchronization
OT  - gamma rhythm
OT  - prodromal symptoms
OT  - psychotic disorders
OT  - social adjustment
EDAT- 2020/12/29 06:00
MHDA- 2021/10/01 06:00
CRDT- 2020/12/28 10:08
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/10/01 06:00 [medline]
PHST- 2020/12/28 10:08 [entrez]
AID - 10.1177/1550059420982706 [doi]
PST - ppublish
SO  - Clin EEG Neurosci. 2021 Nov;52(6):400-405. doi: 10.1177/1550059420982706. Epub 
      2020 Dec 23.