PMID- 33359357
OWN - NLM
STAT- MEDLINE
DCOM- 20210617
LR  - 20220531
IS  - 1096-1208 (Electronic)
IS  - 0882-4010 (Linking)
VI  - 150
DP  - 2021 Jan
TI  - Lung CD103(+) Dendritic cells of mice infected with Paracoccidioides brasiliensis 
      contribute to Treg differentiation.
PG  - 104696
LID - S0882-4010(20)31062-7 [pii]
LID - 10.1016/j.micpath.2020.104696 [doi]
AB  - The DC subsets that express alphaE integrin (CD103) have been described to exert 
      antagonistic functions, driving T cells towards either an inflammatory (Th1/Th17) 
      or immunosuppressive phenotype (regulatory T cells - Treg). These functions 
      depend on the tissue they reside and microenvironment factors or stimuli that 
      this Antigen-presenting cell (APC) subpopulation receive. In this regard, 
      immunoregulatory phenotype has been described in small subsets of CD103(+) DCs 
      from lung and intestinal mucosa. The function of this APC subpopulation in 
      pulmonary Paracoccidioides brasiliensis infection is poorly described. Here, we 
      showed that lung CD103(+) DCs contribute to Treg differentiation in a pulmonary 
      P. brasiliensis infection model, which was attributed to downregulation of 
      costimulatory molecules analyzed in these APC subtypes 21 days post-infection. 
      Overall, this data suggests that P. brasiliensis infection caused an 
      immunosuppression that has also been observed in patients with the most severe 
      form of Paracoccidioidomycosis (PCM) - a sickness caused by this fungus genus. 
      Furthermore, these results open new perspectives for knowledge of the mechanisms 
      that underlie the higher percentage of Treg cells found in peripheral blood of 
      PCM patients.
CI  - Copyright (c) 2020 Elsevier Ltd. All rights reserved.
FAU - Peron, Gabriela
AU  - Peron G
AD  - Department of Structural and Functional Biology, Institute of Biology, State 
      University of Campinas, Campinas, SP, Brazil. Electronic address: 
      g163945@dac.unicamp.br.
FAU - Oliveira, Janine
AU  - Oliveira J
AD  - Department of Structural and Functional Biology, Institute of Biology, State 
      University of Campinas, Campinas, SP, Brazil.
FAU - Fernandes, Fabricio Freitas
AU  - Fernandes FF
AD  - Institute of Health Sciences, Paulista University, Ribeirao Preto, SP, Brazil.
FAU - Verinaud, Liana
AU  - Verinaud L
AD  - Department of Structural and Functional Biology, Institute of Biology, State 
      University of Campinas, Campinas, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20201228
PL  - England
TA  - Microb Pathog
JT  - Microbial pathogenesis
JID - 8606191
RN  - 0 (Antigens, CD)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD
MH  - Cell Differentiation
MH  - Dendritic Cells
MH  - Humans
MH  - Integrin alpha Chains
MH  - Lung
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Paracoccidioides
MH  - *Paracoccidioidomycosis
MH  - T-Lymphocytes, Regulatory
OTO - NOTNLM
OT  - CD103
OT  - Dendritic cells
OT  - Lung antigen-presenting cells
OT  - Paracoccidioides brasiliensis
OT  - Regulatory T cell
EDAT- 2020/12/29 06:00
MHDA- 2021/06/22 06:00
CRDT- 2020/12/28 10:46
PHST- 2020/06/22 00:00 [received]
PHST- 2020/12/05 00:00 [revised]
PHST- 2020/12/09 00:00 [accepted]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2020/12/28 10:46 [entrez]
AID - S0882-4010(20)31062-7 [pii]
AID - 10.1016/j.micpath.2020.104696 [doi]
PST - ppublish
SO  - Microb Pathog. 2021 Jan;150:104696. doi: 10.1016/j.micpath.2020.104696. Epub 2020 
      Dec 28.