PMID- 33359937 OWN - NLM STAT- MEDLINE DCOM- 20210705 LR - 20210705 IS - 2213-7173 (Electronic) IS - 2213-7165 (Linking) VI - 24 DP - 2021 Mar TI - Risk factors and outcomes associated with vancomycin-resistant Enterococcus faecium and ampicillin-resistant Enterococcus faecalis bacteraemia: A 10-year study in a tertiary-care centre in Mexico City. PG - 198-204 LID - S2213-7165(20)30319-2 [pii] LID - 10.1016/j.jgar.2020.12.005 [doi] AB - OBJECTIVES: We sought to identify risk factors associated with vancomycin-resistant Enterococcus faecium (VRE) and ampicillin-resistant Enterococcus faecalis (ARE) bacteraemia, predictors of 30-day mortality, and 90-day recurrence-free survival according to resistance. METHODS: We evaluated clinical records of patients with E. faecalis and E. faecium bacteraemia (2007-2017). We performed bivariate and multivariate logistic regression analyses to identify factors associated with VRE and ARE bacteraemia and predictors of 30-day mortality. A Kaplan-Meier estimate of 90-day recurrence-free survival was done. RESULTS: We identified 192 and 147 E. faecium and E. faecalis bacteraemia episodes, respectively, of which 55.7% of E. faecium were VRE (94% vanA) and 12.2% of E. faecalis were ARE. Factors related to VRE bacteraemia were previous hospitalisation (aOR, 80.18, 95% CI 1.81-634), history of central venous catheter (aOR, 11.15, 95% CI 2.48-50.2) and endotracheal cannula use (aOR, 17.91, 95% CI 1.22-262.82). There was higher attributable mortality to VRE (28%, 95% CI 14-68%; P < 0.001) and ARE (10%, 95% CI 0.1-36%; P = 0.58) compared with their susceptible counterparts. APACHE II (aOR, 1.45, 95% CI 1.26-1.66) and history of chemotherapy (aOR, 3.52, 95% CI 1.09-11.39) were predictors of E. faecium bacteraemia 30-day mortality. We could not recognise any factor related to ARE bacteraemia or E. faecalis 30-day mortality. CONCLUSION: History of hospitalisation and invasive device use were related to VRE bacteraemia. APACHE II and history of chemotherapy were predictors of mortality. We could not identify factors related to ARE or predictors of mortality. CI - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lopez-Luis, Bruno Ali AU - Lopez-Luis BA AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Sifuentes-Osornio, Jose AU - Sifuentes-Osornio J AD - Department of Medicine, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Lambrano-Castillo, Darwin AU - Lambrano-Castillo D AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Ortiz-Brizuela, Edgar AU - Ortiz-Brizuela E AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Ramirez-Fontes, Andrea AU - Ramirez-Fontes A AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Tovar-Calderon, Yanet Estrella AU - Tovar-Calderon YE AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Leal-Vega, Francisco Javier AU - Leal-Vega FJ AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Bobadilla-Del-Valle, Miriam AU - Bobadilla-Del-Valle M AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. FAU - Ponce-de-Leon, Alfredo AU - Ponce-de-Leon A AD - Laboratory of Clinical Microbiology, Department of Infectious Diseases, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Avenida Vasco de Quiroga No. 15, Colonia Belisario Dominguez Seccion XVI, Delegacion Tlalpan, 14080, Mexico City, Mexico. Electronic address: alf.poncedeleon@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20201224 PL - Netherlands TA - J Glob Antimicrob Resist JT - Journal of global antimicrobial resistance JID - 101622459 RN - 6Q205EH1VU (Vancomycin) RN - 7C782967RD (Ampicillin) SB - IM MH - Ampicillin/pharmacology MH - *Bacteremia MH - Enterococcus faecalis MH - *Enterococcus faecium MH - *Gram-Positive Bacterial Infections/epidemiology MH - Humans MH - Mexico/epidemiology MH - Risk Factors MH - Vancomycin OTO - NOTNLM OT - Bacteraemia OT - Enterococcus OT - Vancomycin resistance OT - beta-Lactam resistance EDAT- 2020/12/29 06:00 MHDA- 2021/07/06 06:00 CRDT- 2020/12/28 10:55 PHST- 2020/09/14 00:00 [received] PHST- 2020/10/31 00:00 [revised] PHST- 2020/12/06 00:00 [accepted] PHST- 2020/12/29 06:00 [pubmed] PHST- 2021/07/06 06:00 [medline] PHST- 2020/12/28 10:55 [entrez] AID - S2213-7165(20)30319-2 [pii] AID - 10.1016/j.jgar.2020.12.005 [doi] PST - ppublish SO - J Glob Antimicrob Resist. 2021 Mar;24:198-204. doi: 10.1016/j.jgar.2020.12.005. Epub 2020 Dec 24.