PMID- 33360733
OWN - NLM
STAT- MEDLINE
DCOM- 20210514
LR  - 20210514
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 421
DP  - 2021 Feb 15
TI  - Diagnosis of multiple sclerosis in times of MOG and AQP4 autoantibody testing - A 
      monocentric study.
PG  - 117289
LID - S0022-510X(20)30625-0 [pii]
LID - 10.1016/j.jns.2020.117289 [doi]
AB  - BACKGROUND: Myelin oligodendrocyte glycoprotein-IgG-associated encephalomyelitis 
      (MOG-EM) and neuromyelitis optica spectrum disorders are challenging differential 
      diagnoses of multiple sclerosis (MS). Hence, there is uncertainty, whether to 
      test all MS patients for corresponding antibodies. Our objective was to provide a 
      systematic study on the frequency of MOG and Aquaporin-4 (AQP4) autoantibodies in 
      MS patients to evaluate a possible risk of misclassification. METHODS: 
      Retrospective study in MS patients (including an unselected cohort of patients 
      diagnosed with MS, a cohort of patients with PPMS and a healthy control group) 
      for seroprevalence of MOG and AQP4 autoantibodies by cell-based assay. RESULTS: 
      None of 241 patients with relapsing-remitting, 19 with secondary progressive and 
      82 with primary progressive MS revealed MOG or AQP4 autoantibodies. CONCLUSION: 
      General testing of MOG and AQP4 autoantibodies in MS patients seems not 
      necessary, but should be limited to selected cases only.
CI  - Copyright (c) 2020 Elsevier B.V. All rights reserved.
FAU - Weber, Juliane
AU  - Weber J
AD  - Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, 
      Faculty of Medicine, University of Freiburg, Germany.
FAU - Bernsdorff, Nora
AU  - Bernsdorff N
AD  - Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, 
      Faculty of Medicine, University of Freiburg, Germany.
FAU - Robinson, Tilman
AU  - Robinson T
AD  - Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, 
      Faculty of Medicine, University of Freiburg, Germany.
FAU - Endres, Dominique
AU  - Endres D
AD  - Department of Psychiatry and Psychotherapy, Medical Center - University of 
      Freiburg, Faculty of Medicine, University of Freiburg, Germany.
FAU - Rauer, Sebastian
AU  - Rauer S
AD  - Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, 
      Faculty of Medicine, University of Freiburg, Germany.
FAU - Berger, Benjamin
AU  - Berger B
AD  - Clinic of Neurology and Neurophysiology, Medical Center - University of Freiburg, 
      Faculty of Medicine, University of Freiburg, Germany. Electronic address: 
      benjamin.berger@uniklinik-freiburg.de.
LA  - eng
PT  - Journal Article
DEP - 20201220
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Aquaporin 4)
RN  - 0 (Autoantibodies)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Aquaporin 4
MH  - Autoantibodies
MH  - Humans
MH  - *Multiple Sclerosis/diagnosis
MH  - Myelin-Oligodendrocyte Glycoprotein
MH  - *Neuromyelitis Optica/diagnosis
MH  - Retrospective Studies
MH  - Seroepidemiologic Studies
OTO - NOTNLM
OT  - Aquaporin-4
OT  - MOG
OT  - McDonald criteria
OT  - Multiple sclerosis
OT  - Myelin oligodendrocyte glycoprotein
OT  - Neuromyelitis optica spectrum disorders
EDAT- 2020/12/29 06:00
MHDA- 2021/05/15 06:00
CRDT- 2020/12/28 11:28
PHST- 2020/10/06 00:00 [received]
PHST- 2020/11/25 00:00 [revised]
PHST- 2020/12/18 00:00 [accepted]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/05/15 06:00 [medline]
PHST- 2020/12/28 11:28 [entrez]
AID - S0022-510X(20)30625-0 [pii]
AID - 10.1016/j.jns.2020.117289 [doi]
PST - ppublish
SO  - J Neurol Sci. 2021 Feb 15;421:117289. doi: 10.1016/j.jns.2020.117289. Epub 2020 
      Dec 20.