PMID- 33361186
OWN - NLM
STAT- MEDLINE
DCOM- 20211118
LR  - 20211118
IS  - 1535-5675 (Electronic)
IS  - 0091-4916 (Linking)
VI  - 49
IP  - 2
DP  - 2021 Jun
TI  - The Utility of Adding a Liquid-Nutrient Meal to Aid Interpretation of Small-Bowel 
      Transit Scintigraphy.
PG  - 132-137
LID - 10.2967/jnmt.120.255091 [doi]
AB  - Small-bowel transit scintigraphy (SBTS) evaluates the accumulation of a 
      radiolabeled meal in the terminal ileal reservoir (TIR) 6 h after ingestion. The 
      location of the TIR may be difficult to determine because anatomic information is 
      limited; for equivocal studies, the patient is asked to return the next day to 
      help determine the TIR location by potential transit into the colon. The purpose 
      of this study was to evaluate whether administration of an additional 
      liquid-nutrient meal (LNM) at 6 h can promote movement of the radiolabeled meal 
      to aid in the interpretation of SBTS and eliminate the need for the patient to 
      return. Methods: This retrospective study reviewed 117 SBTS studies from February 
      2017 to September 2019. Patients were fed a standardized mixed radiolabeled 
      solid-liquid meal for gastric emptying with SBTS according to Society of Nuclear 
      Medicine and Molecular Imaging practice guidelines. An additional LNM was given 
      at 6 h, and post-LNM images were obtained at least 20 min after the LNM. Two 
      board-certified nuclear medicine physicians independently evaluated all images as 
      equivocal or diagnostic at 6 h. Results: Of the 117 patients (71.8% female; 
      median age, 42.0 y) undergoing SBTS, 37 were equivocal cases at 6 h before the 
      LNM (31.6%; 95% CI, 23.3%-40.9%), compared with 12 equivocal cases after the LNM 
      (10.3%; 95% CI, 5.4%-17.2%). Of the equivocal cases, 25 (69.4%; 95% CI, 
      51.9%-83.7%) had a definitive result after the LNM, whereas 11 (30.6%; 95% CI, 
      16.4%-48.1%) remained equivocal and 1 showed rapid transit. Among the 23 patients 
      with gastroparesis, only 13 (57%) responded to the LNM, and none of the 3 
      patients with irritable bowel syndrome responded. Conclusion: The number of 
      equivocal SBTS cases decreased after administration of an LNM at 6 h, converting 
      to a definitive result. This suggests that with use of an LNM, most patients can 
      complete SBTS in 1 d without the need for repeat imaging at 24 h. Administering 
      an LNM appears to be less effective for patients with gastric disorders. However, 
      the clinical significance remains to be explored, and it is unclear whether such 
      patients have both a gastric and a small-bowel disorder, hence reducing any 
      motility-promoting effect of the LNM.
CI  - (c) 2021 by the Society of Nuclear Medicine and Molecular Imaging.
FAU - Selby, Alexandra
AU  - Selby A
AD  - Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania.
FAU - Yeung, Ho-Man
AU  - Yeung HM
AD  - Department of Medicine, Temple University Hospital, Philadelphia, Pennsylvania.
FAU - Yu, Daohai
AU  - Yu D
AD  - Department of Clinical Sciences, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, Pennsylvania.
FAU - Goldbach, Alyssa
AU  - Goldbach A
AD  - Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; 
      and.
FAU - Lu, Xiaoning
AU  - Lu X
AD  - Department of Clinical Sciences, Lewis Katz School of Medicine at Temple 
      University, Philadelphia, Pennsylvania.
FAU - Parkman, Henry P
AU  - Parkman HP
AD  - Department of Gastroenterology, Temple University Hospital, Philadelphia, 
      Pennsylvania.
FAU - Kamat, Bhishak
AU  - Kamat B
AD  - Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; 
      and.
FAU - Maurer, Alan H
AU  - Maurer AH
AD  - Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; 
      and.
AD  - Department of Gastroenterology, Temple University Hospital, Philadelphia, 
      Pennsylvania.
FAU - Dadparvar, Simin
AU  - Dadparvar S
AD  - Department of Radiology, Temple University Hospital, Philadelphia, Pennsylvania; 
      and simindokht.dadparvar@tuhs.temple.edu.
LA  - eng
PT  - Letter
DEP - 20201224
PL  - United States
TA  - J Nucl Med Technol
JT  - Journal of nuclear medicine technology
JID - 0430303
SB  - IM
MH  - Adult
MH  - Colon
MH  - Female
MH  - Gastric Emptying
MH  - Gastrointestinal Transit
MH  - Humans
MH  - Male
MH  - *Nutrients
MH  - Radionuclide Imaging
MH  - Retrospective Studies
OTO - NOTNLM
OT  - gastrointestinal dysmotility
OT  - gastroparesis
OT  - irritable bowel syndrome
OT  - liquid-nutrient meal
OT  - small-bowel transit scintigraphy
EDAT- 2020/12/29 06:00
MHDA- 2021/11/19 06:00
CRDT- 2020/12/28 11:40
PHST- 2020/08/09 00:00 [received]
PHST- 2020/12/04 00:00 [accepted]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2020/12/28 11:40 [entrez]
AID - jnmt.120.255091 [pii]
AID - 10.2967/jnmt.120.255091 [doi]
PST - ppublish
SO  - J Nucl Med Technol. 2021 Jun;49(2):132-137. doi: 10.2967/jnmt.120.255091. Epub 
      2020 Dec 24.