PMID- 33361747
OWN - NLM
STAT- MEDLINE
DCOM- 20210520
LR  - 20210520
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 26
DP  - 2020 Dec 26
TI  - Laryngeal Squamous Cell Carcinoma: Potential Molecular Mechanism and Prognostic 
      Signature Based on Immune-Related Genes.
PG  - e928185
LID - 10.12659/MSM.928185 [doi]
AB  - BACKGROUND Immune-related genes (IRGs) are closely related to the incidence and 
      progression of tumors, potentially indicating that IRGs play an important role in 
      laryngeal squamous cell carcinoma (LSCC). MATERIAL AND METHODS An RNA sequencing 
      dataset containing 123 samples was collected from The Cancer Genome Atlas. Based 
      on immune-related differentially expressed genes (IRDEGs), a potential molecular 
      mechanism of LSCC was explored through analysis of information in the Gene 
      Ontology (GO) resource and the Kyoto Encyclopedia of Genes and Genomes (KEGG), 
      and protein-protein interactions (PPIs). A regulatory network of transcriptional 
      regulators and IRDEGs was constructed to explore the underlying molecular 
      mechanism of LSCC at the upstream level. Candidates from IRDEGs for signature 
      were screened via univariate Cox analysis and using the least absolute shrinkage 
      and selection operator (LASSO) technique. The IRDEG signature of LSCC was 
      constructed by using a multivariate Cox proportional hazards model. RESULTS GO 
      and KEGG analysis showed that IRDEGs may participate in the progression of LSCC 
      through immune-related reactions. PPI analysis demonstrated that, among the 
      IRDEGs in LSCC, the Kininogen 1; C-X-X motif chemokine ligand 10; elastase, 
      neutrophil expressed; and LYZ genes are hub genes in the development of LSCC. At 
      the upstream level, SPI1, SP140, signal transducer and activator of transcription 
      4, zinc finger E-box binding homeobox, and Ikaros family zinc finger 2 are the 
      hub transcriptional regulators of IRDEGs. The risk score based on the IRDEG 
      signature was able to distinguish prognosis in patients with LSCC and represents 
      an independent prognostic risk factor for LSCC. CONCLUSIONS From the perspective 
      of IRGs, we first constructed an IRDEG signature related to the prognosis of 
      LSCC, which can be used as a novel marker to predict prognosis in patients with 
      LSCC.
FAU - Mo, Bin-Yu
AU  - Mo BY
AD  - Department of Otolaryngology, Liuzhou People's Hospital of Guangxi, Liuzhou, 
      Guangxi, China (mainland).
FAU - Li, Guo-Sheng
AU  - Li GS
AD  - Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, China (mainland).
FAU - Huang, Su-Ning
AU  - Huang SN
AD  - Department of Radiotherapy, Guangxi Medical University Cancer Hospital, Nanning, 
      Guangxi, China (mainland).
FAU - Wei, Zhu-Xin
AU  - Wei ZX
AD  - Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, China (mainland).
FAU - Su, Ya-Si
AU  - Su YS
AD  - Department of Pathology, Liuzhou People's Hospital, Liuzhou, Guangxi, China 
      (mainland).
FAU - Dai, Wen-Bin
AU  - Dai WB
AD  - Department of Pathology, Liuzhou People's Hospital, Liuzhou, Guangxi, China 
      (mainland).
FAU - Ruan, Lin
AU  - Ruan L
AD  - Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical 
      University, Nanning, Guangxi, China (mainland).
LA  - eng
PT  - Journal Article
DEP - 20201226
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Carcinoma, Squamous Cell/diagnosis/*genetics/*immunology
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Neoplastic
MH  - Gene Ontology
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Laryngeal Neoplasms/diagnosis/*genetics/*immunology
MH  - Nomograms
MH  - Prognosis
MH  - Protein Interaction Maps/genetics
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Transcription Factors/metabolism
MH  - Up-Regulation/genetics
PMC - PMC7772955
COIS- Conflicts of interest None.
EDAT- 2020/12/29 06:00
MHDA- 2021/05/21 06:00
PMCR- 2020/12/26
CRDT- 2020/12/28 11:45
PHST- 2020/12/28 11:45 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2021/05/21 06:00 [medline]
PHST- 2020/12/26 00:00 [pmc-release]
AID - 928185 [pii]
AID - 10.12659/MSM.928185 [doi]
PST - epublish
SO  - Med Sci Monit. 2020 Dec 26;26:e928185. doi: 10.12659/MSM.928185.