PMID- 33362126 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20201229 LR - 20201229 IS - 1520-8532 (Electronic) IS - 1084-7529 (Linking) VI - 37 IP - 12 DP - 2020 Dec 1 TI - Evaluation of temporal moments and Fourier transformed data in time-domain diffuse optical tomography. PG - 1845-1856 LID - 10.1364/JOSAA.405541 [doi] AB - Time-domain diffuse optical tomography (TD-DOT) uses near-infrared pulsed lasers as light sources to measure time-varying exitance on the boundary of the target. These are used to estimate optical properties of the imaged target. Several integral-transform-based moments of the time-resolved data have been utilized in TD-DOT, the most common being the mean time of flight and variance. Recently, it has been shown that Fourier transforming the time-domain data to frequency domain enables utilization of these data at one or several frequencies, producing equally as good estimates as the whole time-domain data. In this work, we present a systematic comparison of the usage of the temporal moments and Fourier transformed data in TD-DOT. Both absolute and difference imaging are evaluated using numerical simulations. The simulations show that utilizing temporal moments and Fourier transformed data in TD-DOT provides good quality reconstructions with a good estimation accuracy. These estimates are improved if more than one data type is used. Furthermore, the simulations show that the frequency-domain computations enable computationally cheaper and straightforward implementation of the inverse solver when compared to the temporal moments. FAU - Mozumder, Meghdoot AU - Mozumder M FAU - Tarvainen, Tanja AU - Tarvainen T LA - eng PT - Journal Article PL - United States TA - J Opt Soc Am A Opt Image Sci Vis JT - Journal of the Optical Society of America. A, Optics, image science, and vision JID - 9800943 SB - IM EDAT- 2020/12/29 06:00 MHDA- 2020/12/29 06:01 CRDT- 2020/12/28 11:53 PHST- 2020/12/28 11:53 [entrez] PHST- 2020/12/29 06:00 [pubmed] PHST- 2020/12/29 06:01 [medline] AID - 442110 [pii] AID - 10.1364/JOSAA.405541 [doi] PST - ppublish SO - J Opt Soc Am A Opt Image Sci Vis. 2020 Dec 1;37(12):1845-1856. doi: 10.1364/JOSAA.405541.