PMID- 33362498
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201229
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 14
DP  - 2020
TI  - Abnormal Whole Brain Functional Connectivity Pattern Homogeneity and Couplings in 
      Migraine Without Aura.
PG  - 619839
LID - 10.3389/fnhum.2020.619839 [doi]
LID - 619839
AB  - Previous studies have reported abnormal amplitude of low-frequency fluctuation 
      and regional homogeneity in patients with migraine without aura using 
      resting-state functional magnetic resonance imaging. However, how whole brain 
      functional connectivity pattern homogeneity and its corresponding functional 
      connectivity changes in patients with migraine without aura is unknown. In the 
      current study, we employed a recently developed whole brain functional 
      connectivity homogeneity (FcHo) method to identify the voxel-wise changes of 
      functional connectivity patterns in 21 patients with migraine without aura and 21 
      gender and age matched healthy controls. Moreover, resting-state functional 
      connectivity analysis was used to reveal the changes of corresponding functional 
      connectivities. FcHo analyses identified significantly decreased FcHo values in 
      the posterior cingulate cortex (PCC), thalamus (THA), and left anterior insula 
      (AI) in patients with migraine without aura compared to healthy controls. 
      Functional connectivity analyses further found decreased functional 
      connectivities between PCC and medial prefrontal cortex (MPFC), between AI and 
      anterior cingulate cortex, and between THA and left precentral gyrus (PCG). The 
      functional connectivities between THA and PCG were negatively correlated with 
      pain intensity. Our findings indicated that whole brain FcHo and connectivity 
      abnormalities of these regions may be associated with functional impairments in 
      pain processing in patients with migraine without aura.
CI  - Copyright (c) 2020 Zhang, Chen, Zeng, He, Qi, Zhang and Liu.
FAU - Zhang, Yingxia
AU  - Zhang Y
AD  - Department of Radiology, West China Hospital of Sichuan University, Chengdu, 
      China.
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - Chen, Hong
AU  - Chen H
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - Zeng, Min
AU  - Zeng M
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - He, Junwei
AU  - He J
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - Qi, Guiqiang
AU  - Qi G
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - Zhang, Shaojin
AU  - Zhang S
AD  - Department of Radiology, The Third Affiliated Hospital of Chengdu Medical 
      College, Pidu District People's Hospital, Chengdu, China.
FAU - Liu, Rongbo
AU  - Liu R
AD  - Department of Radiology, West China Hospital of Sichuan University, Chengdu, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20201211
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC7759668
OTO - NOTNLM
OT  - FCHo
OT  - functional connectivity
OT  - functional magnetic resonance imaging
OT  - migraine without aura
OT  - resting-state
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/01/01
CRDT- 2020/12/28 11:55
PHST- 2020/10/21 00:00 [received]
PHST- 2020/11/18 00:00 [accepted]
PHST- 2020/12/28 11:55 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2020.619839 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2020 Dec 11;14:619839. doi: 10.3389/fnhum.2020.619839. 
      eCollection 2020.