PMID- 33362527
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201229
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 12
DP  - 2020
TI  - Effect of Bone Marrow Stromal Cells in Parkinson's Disease Rodent Model: A 
      Meta-Analysis.
PG  - 539933
LID - 10.3389/fnagi.2020.539933 [doi]
LID - 539933
AB  - Background: Bone marrow stromal cells (BMSCs) has been reported to have 
      beneficial effects in improving behavioral deficits, and rescuing dopaminergic 
      neuron loss in rodent models of Parkinson's disease (PD). However, their pooled 
      effects for dopaminergic neuron have yet to be described. Objective: To review 
      the neuroprotective effect of naive BMSCs in rodent models of PD. Methods: The 
      PubMed, EMBASE, and Web of Science databases were searched up to September 30, 
      2020. Inclusion criteria according to PICOS criteria were as follows: (1) 
      population: rodents; (2) intervention: unmodified BMSCs; (3) comparison: not 
      specified; (4) primary outcome: tyrosine hydroxylase level in the substantia 
      nigra pars compacta and rotational behavior; secondary outcome: rotarod test, and 
      limb function; (5) study: experimental studies. Multiple prespecified subgroup 
      and meta-regression analysis were conducted. Following quality assessment, random 
      effects models were used for this meta-analysis. Results: Twenty-seven animal 
      studies were included. The median quality score was 4.7 (interquartile range, 
      2-8). Overall standardized mean difference between animals treated with naive 
      BMSCs and controls was 2.79 (95% confidence interval: 1.70, 3.87; P < 0.001) for 
      densitometry of tyrosine hydroxylase-positive staining; -1.54 (95% confidence 
      interval: -2.11, -0.98; P < 0.001) for rotational behavior. Significant 
      heterogeneity among studies was observed. Conclusions: Results of this 
      meta-analysis suggest that naive BMSCs therapy increased dopaminergic neurons and 
      ameliorated behavioral deficits in rodent models of PD.
CI  - Copyright (c) 2020 Liu, He, Huang and Hu.
FAU - Liu, Jianyang
AU  - Liu J
AD  - Department of Neurology, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - He, Jialin
AU  - He J
AD  - Department of Neurology, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Huang, Yan
AU  - Huang Y
AD  - Department of Neurology, Second Xiangya Hospital, Central South University, 
      Changsha, China.
FAU - Hu, Zhiping
AU  - Hu Z
AD  - Department of Neurology, Second Xiangya Hospital, Central South University, 
      Changsha, China.
LA  - eng
PT  - Systematic Review
DEP - 20201211
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC7759665
OTO - NOTNLM
OT  - Parkinson's disease
OT  - animal experimentation
OT  - bone marrow stromal cell
OT  - efficacy
OT  - meta-analysis
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/01/01
CRDT- 2020/12/28 11:55
PHST- 2020/03/03 00:00 [received]
PHST- 2020/11/23 00:00 [accepted]
PHST- 2020/12/28 11:55 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2020.539933 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2020 Dec 11;12:539933. doi: 10.3389/fnagi.2020.539933. 
      eCollection 2020.