PMID- 33362965
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 8
DP  - 2020
TI  - Urinary MMP-9/UCr association with albumin concentration and 
      albumin-creatinine-ratio in Mexican patients with type 2 diabetes mellitus.
PG  - e10474
LID - 10.7717/peerj.10474 [doi]
LID - e10474
AB  - BACKGROUND: Chronic kidney disease is one of the most common complications of 
      type 2 diabetes mellitus (T2DM), causing an increased risk of cardiovascular 
      morbidity and mortality. Matrix metalloproteinase (MMP) activity has been 
      proposed as useful biomarker for diabetic renal and vascular complications. 
      METHODS: A cross-sectional study was conducted among T2DM patients who attended a 
      public secondary hospital in Mexico. We performed clinical, biochemical, and 
      microbiological assessments, as well chronic kidney disease diagnosis according 
      to the KDIGO guideline. Urinary MMP-9 was quantified by ELISA and adjusted using 
      urinary creatinine (UCr). RESULTS: A total of 111 patients were included. Most 
      participants were women (66%). Mean age was 61 +/- 10 years and median T2DM 
      duration was estimated at 11 years. Through multivariate analysis, MMP-9/UCr was 
      found to be associated with albumin concentration and albumin to creatinine 
      ratio. DISCUSSION: Validation of non-invasive biomarkers of chronic kidney 
      disease among T2DM patients is necessary. Here, we demonstrate MMP-9/UCr as a 
      potential biomarker of albumin concentration and albumin to creatinine ratio in 
      Mexican patients with T2DM.
CI  - (c)2020 Arcos-Sacramento et al.
FAU - Arcos-Sacramento, Victor Gildardo
AU  - Arcos-Sacramento VG
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Sampieri, Clara Luz
AU  - Sampieri CL
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Sandoval-Lozano, Victor Hugo
AU  - Sandoval-Lozano VH
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Orozco-Ortega, Ruben Arturo
AU  - Orozco-Ortega RA
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Acuna-Hernandez, Mariel Alejandra
AU  - Acuna-Hernandez MA
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Morales-Romero, Jaime
AU  - Morales-Romero J
AD  - Instituto de Salud Publica, Universidad Veracruzana, Xalapa, Veracruz, Mexico.
FAU - Hernandez-Hernandez, Magda Elena
AU  - Hernandez-Hernandez ME
AD  - Secretaria de Salud del Estado de Veracruz, Xalapa, Veracruz, Mexico.
FAU - Rodriguez-Hernandez, Arturo
AU  - Rodriguez-Hernandez A
AD  - Instituto Mexicano del Seguro Social, Unidad de Medicina Familiar No. 10, Xalapa, 
      Veracruz, Mexico.
LA  - eng
PT  - Journal Article
DEP - 20201216
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC7749659
OTO - NOTNLM
OT  - Chronic Kidney Disease
OT  - Diabetes mellitus
OT  - Matrix Metalloproteinases
COIS- The authors declare there are no competing interests.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/12/16
CRDT- 2020/12/28 11:57
PHST- 2020/08/14 00:00 [received]
PHST- 2020/11/11 00:00 [accepted]
PHST- 2020/12/28 11:57 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/12/16 00:00 [pmc-release]
AID - 10474 [pii]
AID - 10.7717/peerj.10474 [doi]
PST - epublish
SO  - PeerJ. 2020 Dec 16;8:e10474. doi: 10.7717/peerj.10474. eCollection 2020.