PMID- 33363399
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220419
IS  - 1178-7074 (Print)
IS  - 1178-7074 (Electronic)
IS  - 1178-7074 (Linking)
VI  - 13
DP  - 2020
TI  - Pump Proton and Laryngeal H(+)/K(+) ATPases.
PG  - 1509-1514
LID - 10.2147/IJGM.S284952 [doi]
AB  - PURPOSE: The presence of extra-gastric H(+)/K(+) ATPases may explain the 
      clinically significant effect of proton pump inhibitor (PPI) pharmacotherapy in 
      patients with chronic laryngitis related to laryngopharyngeal reflux disease 
      (LPRD) but without gastroesophageal reflux disease (GERD) symptoms. Given the 
      need for a better understanding of GERD and LPRD, we review the various proton 
      pumps with respect to their classification, function, and distribution. We then 
      consider the potential role of the laryngeal H(+)/K(+) ATPase pump in LPRD. 
      METHODS: We searched databases of PubMed, EMBASE, and Web of Science to achieve 
      related published before September 15, 2020. RESULTS: There were only seven 
      English-literatures meeting inclusive criteria about laryngeal H(+)/K(+) ATPases. 
      Some studies provide convincing evidence of a laryngeal H(+)/K(+) ATPase in 
      normal laryngeal tissues but also suggest the potential role of the proton pump 
      in the abnormal mucus secretion frequently seen in patients with chronic 
      laryngitis. CONCLUSION: A laryngeal H(+)/K(+) ATPase expresses in normal 
      laryngeal tissues. These findings question the current understanding of GERD and 
      LPRD.
CI  - (c) 2020 Zhang et al.
FAU - Zhang, Zhe
AU  - Zhang Z
AD  - Department of Otolaryngology, Peoples Hospital of Yuyao City, Yuyao 315400, 
      Zhejiang, People's Republic of China.
FAU - Bao, Yang-Yang
AU  - Bao YY
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China.
FAU - Zhou, Shui-Hong
AU  - Zhou SH
AUID- ORCID: 0000-0002-7163-2289
AD  - Department of Otolaryngology, The First Affiliated Hospital, College of Medicine, 
      Zhejiang University, Hangzhou, Zhejiang 310003, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201214
PL  - New Zealand
TA  - Int J Gen Med
JT  - International journal of general medicine
JID - 101515487
PMC - PMC7754099
OTO - NOTNLM
OT  - H+/K+ ATPases
OT  - chronic laryngitis
OT  - gastroesophageal reflux disease
OT  - laryngopharyngeal reflux disease
OT  - larynx
OT  - proton pump
COIS- The authors report no conflicts of interest in this work.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/12/14
CRDT- 2020/12/28 11:59
PHST- 2020/10/01 00:00 [received]
PHST- 2020/11/20 00:00 [accepted]
PHST- 2020/12/28 11:59 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/12/14 00:00 [pmc-release]
AID - 284952 [pii]
AID - 10.2147/IJGM.S284952 [doi]
PST - epublish
SO  - Int J Gen Med. 2020 Dec 14;13:1509-1514. doi: 10.2147/IJGM.S284952. eCollection 
      2020.