PMID- 33364336
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220425
IS  - 2352-9067 (Print)
IS  - 2352-9067 (Electronic)
IS  - 2352-9067 (Linking)
VI  - 32
DP  - 2021 Feb
TI  - Neutrophil gelatinase-associated lipocalin (NGAL) for the prediction of acute 
      kidney injury in chronic kidney disease patients treated with primary 
      percutaneous coronary intervention.
PG  - 100695
LID - 10.1016/j.ijcha.2020.100695 [doi]
LID - 100695
AB  - INTRODUCTION: Elevated plasma levels of neutrophil gelatinase-associated 
      lipocalin (NGAL) is a marker of tubular damage and aid in the early 
      identification of acute kidney injury (AKI). We evaluated NGAL levels for 
      identification of AKI superimposed on chronic kidney disease (CKD) vs. "de novo" 
      AKI among ST elevation myocardial infarction (STEMI) patients undergoing primary 
      coronary intervention (PCI). METHODS: 217 STEMI patients treated with PCI were 
      prospectively included, 34 (16%) had baseline CKD. Plasma NGAL levels were drawn 
      24 h following PCI. Receiver-operator characteristic (ROC) methods were used to 
      identify optimal sensitivity and specificity for the observed NGAL range in AKI 
      patients with and without CKD. RESULTS: Overall AKI incidence was 13%. NGAL 
      levels were significantly higher for patients with AKI compared to no-AKI, 
      irrespective of CKD. Different optimal cutoff value for NGAL to predict AKI were 
      found for patients with CKD (133 ng/ml, sensitivity of 73% and specificity of 
      75%; AUC: 0.837, p < 0.001) and for non-CKD (104 ng/ml with sensitivity of 79% 
      and specificity of 82%; AUC: 0.844, p < 0.001). In a multivariate logistic 
      regression model, NGAL levels were independently associated with AKI in patients 
      with and without CKD (HR 1.04, 95% CI: 1.01-1.08; p = 0.024; and HR 1.03, 95% CI: 
      1.01-1.04; p = 0.001), respectively. CONCLUSIONS: Elevated plasma NGAL levels 
      identify patients who are at high-risk to develop AKI following primary PCI. 
      Determining different cutoff values of plasma NGAL for de novo AKI and AKI 
      superimposed on CKD may be necessary for accurate AKI diagnosis and risk 
      stratification.
CI  - (c) 2020 The Authors. Published by Elsevier B.V.
FAU - Banai, Ariel
AU  - Banai A
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Rozenfeld, Keren-Lee
AU  - Rozenfeld KL
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Levit, Dana
AU  - Levit D
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Merdler, Ilan
AU  - Merdler I
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Loewenstein, Itamar
AU  - Loewenstein I
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Banai, Shmuel
AU  - Banai S
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - Department of Cardiology, Tel-Aviv Sourasky Medical Center Affiliated to the 
      Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20201217
PL  - Ireland
TA  - Int J Cardiol Heart Vasc
JT  - International journal of cardiology. Heart & vasculature
JID - 101649525
PMC - PMC7753140
OTO - NOTNLM
OT  - AKI
OT  - NGAL
OT  - PCI
OT  - STEMI
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/12/17
CRDT- 2020/12/28 12:02
PHST- 2020/10/22 00:00 [received]
PHST- 2020/11/28 00:00 [revised]
PHST- 2020/12/02 00:00 [accepted]
PHST- 2020/12/28 12:02 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/12/17 00:00 [pmc-release]
AID - S2352-9067(20)30393-6 [pii]
AID - 100695 [pii]
AID - 10.1016/j.ijcha.2020.100695 [doi]
PST - epublish
SO  - Int J Cardiol Heart Vasc. 2020 Dec 17;32:100695. doi: 
      10.1016/j.ijcha.2020.100695. eCollection 2021 Feb.