PMID- 33364409
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240330
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 5
IP  - 6
DP  - 2020 Dec
TI  - Enhanced fallopian canal as a potential marker for temporal bone vasculitis.
PG  - 1168-1175
LID - 10.1002/lio2.489 [doi]
AB  - OBJECTIVES: This study aimed to test the hypothesis that contrast-enhanced 3D MRI 
      with gradient-echo sequences (CE-3D-GRE) can detect signs of vasculitis in the 
      fallopian canal, which may cause otologic involvement, in four patients with 
      antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: 
      CE-3D-GRE acquired at 3.0 Tesla was performed on four patients diagnosed with 
      granulomatosis with polyangiitis or eosinophilic granulomatosis with 
      polyangiitis, at onset or relapse of the disease, and in remission. Clinical 
      correlations between otologic symptoms and radiological findings were examined 
      for each patient. Furthermore, signal intensity of the mastoid segment of the 
      fallopian canal was compared between the ears with active disease (n = 3) and 
      those in remission or without vasculitis (n = 3). RESULTS: Intense enhancement in 
      the tympanic and mastoid segments of the fallopian canal was associated with 
      development of external otitis, otitis media, and sensorineural hearing loss, and 
      was unrelated to the presence of facial paresis. Maximal intensity projection 
      images visualized the close relationship between the enhanced fallopian canal and 
      middle ear inflammation. The findings were absent in remission. Signal intensity 
      of the mastoid segment of the fallopian canal was higher in ears with active 
      disease than in normal ears (P < .001) and decreased to normal levels during 
      remission (P = .597). CONCLUSION: CE-3D-GRE can demonstrate vasculitis in the 
      temporal bone, reflecting disease activity and the severity of otologic 
      manifestations, including cochlear involvement, in AAV patients. Intense 
      enhancement of the fallopian canal on CE-3D-GRE can be a potential marker for 
      vasculitis of the temporal bone. LEVEL OF EVIDENCE: 5.
CI  - (c) 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley 
      Periodicals LLC on behalf of The Triological Society.
FAU - Fujikawa, Taro
AU  - Fujikawa T
AUID- ORCID: 0000-0002-3251-9080
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
FAU - Honda, Keiji
AU  - Honda K
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
FAU - Ito, Taku
AU  - Ito T
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
FAU - Kishino, Mitsuhiro
AU  - Kishino M
AD  - Department of Radiology Tokyo Medical and Dental University Tokyo Japan.
FAU - Kimura, Naoki
AU  - Kimura N
AD  - Department of Rheumatology Tokyo Medical and Dental University Tokyo Japan.
FAU - Umezawa, Natsuka
AU  - Umezawa N
AD  - Department of Rheumatology Tokyo Medical and Dental University Tokyo Japan.
FAU - Hirano, Mana
AU  - Hirano M
AD  - Department of Rheumatology National Defence Medical College Tokorozawa Japan.
FAU - Aoki, Natsuki
AU  - Aoki N
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
FAU - Kawashima, Yoshiyuki
AU  - Kawashima Y
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
FAU - Tsutsumi, Takeshi
AU  - Tsutsumi T
AD  - Department of Otolaryngology Tokyo Medical and Dental University Tokyo Japan.
LA  - eng
PT  - Journal Article
DEP - 20201104
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC7752078
OTO - NOTNLM
OT  - 3D MRI
OT  - eosinophilic granulomatosis with polyangiitis
OT  - granulomatosis with polyangiitis
OT  - otologic involvement
OT  - the fallopian canal
COIS- The authors have no conflicts of interest to disclose related to this article.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/11/04
CRDT- 2020/12/28 12:02
PHST- 2020/07/01 00:00 [received]
PHST- 2020/10/23 00:00 [revised]
PHST- 2020/10/23 00:00 [accepted]
PHST- 2020/12/28 12:02 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/11/04 00:00 [pmc-release]
AID - LIO2489 [pii]
AID - 10.1002/lio2.489 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2020 Nov 4;5(6):1168-1175. doi: 
      10.1002/lio2.489. eCollection 2020 Dec.