PMID- 33364825
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201231
IS  - 1179-1322 (Print)
IS  - 1179-1322 (Electronic)
IS  - 1179-1322 (Linking)
VI  - 12
DP  - 2020
TI  - Regulatory Roles of Tumor Necrosis Factor-alpha-Induced Protein 8 Like-Protein 2 in 
      Inflammation, Immunity and Cancers: A Review.
PG  - 12735-12746
LID - 10.2147/CMAR.S283877 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha)-induced protein 8 (TNFAIP8/TIPE) family, 
      including TNFAIP8 (TIPE), TNFAIP8 like-protein 1 (TNFAIP8L1/TIPE1), TNFAIP8 
      like-protein 2 (TNFAIP8L2/TIPE2), and TNFAIP8 like-protein 3 (TNFAIP8L3/TIPE3), 
      plays a vital role in regulating inflammatory responses, immune homeostasis, and 
      cancer development. Over the last decade, studies have shown that TIPE2 protein 
      is differentially expressed in diverse cells and tissues. The dysregulation of 
      TIPE2 protein can lead to dysregulation of inflammatory responses and immune 
      homeostasis, and change the basic characteristics of cancers. In consideration of 
      the immeasurable values of TIPE2 in diagnosis, treatment, and prognosis of 
      various human diseases, this review will focus on the expression pattern, 
      structure, and regulatory roles of TIPE2 in inflammation, immunity, and cancers.
CI  - (c) 2020 Gu et al.
FAU - Gu, Zhengzhong
AU  - Gu Z
AUID- ORCID: 0000-0002-2835-9619
AD  - Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital 
      of Jilin University, Changchun, Jilin Province, People's Republic of China.
FAU - Cui, Xiaohan
AU  - Cui X
AD  - Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of 
      China.
FAU - Sun, Pengda
AU  - Sun P
AD  - Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital 
      of Jilin University, Changchun, Jilin Province, People's Republic of China.
FAU - Wang, Xudong
AU  - Wang X
AD  - Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital 
      of Jilin University, Changchun, Jilin Province, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201214
PL  - New Zealand
TA  - Cancer Manag Res
JT  - Cancer management and research
JID - 101512700
PMC - PMC7751774
OTO - NOTNLM
OT  - TIPE2
OT  - immune homeostasis
OT  - inflammation
OT  - metastasis
OT  - tumor
OT  - tumorigenesis
COIS- All authors declare no conflicts of interest for this work.
EDAT- 2020/12/29 06:00
MHDA- 2020/12/29 06:01
PMCR- 2020/12/14
CRDT- 2020/12/28 12:04
PHST- 2020/09/25 00:00 [received]
PHST- 2020/11/15 00:00 [accepted]
PHST- 2020/12/28 12:04 [entrez]
PHST- 2020/12/29 06:00 [pubmed]
PHST- 2020/12/29 06:01 [medline]
PHST- 2020/12/14 00:00 [pmc-release]
AID - 283877 [pii]
AID - 10.2147/CMAR.S283877 [doi]
PST - epublish
SO  - Cancer Manag Res. 2020 Dec 14;12:12735-12746. doi: 10.2147/CMAR.S283877. 
      eCollection 2020.