PMID- 33370612 OWN - NLM STAT- MEDLINE DCOM- 20210203 LR - 20210203 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 271 DP - 2021 Feb 15 TI - Acute respiratory response to individual particle exposure (PM(1.0), PM(2.5) and PM(10)) in the elderly with and without chronic respiratory diseases. PG - 116329 LID - S0269-7491(20)37018-4 [pii] LID - 10.1016/j.envpol.2020.116329 [doi] AB - Limited data were on the acute respiratory responses in the elderly in response to personal exposure of particulate matter (PM). In order to evaluate the changes of airway inflammation and pulmonary functions in the elderly in response to individual exposure of particles (PM(1.0), PM(2.5) and PM(10)), we analyzed 43 elderly subjects with either asthma, chronic obstructive pulmonary disease (COPD) or Asthma COPD Overlap (ACO) and 40 age-matched subjects without asthma nor COPD in an urban community in Shanghai, China. Data were collected at the baseline and in 6 follow-ups from August 2016 to December 2018, once every 3 months except for the last twice with a 6-month interval. In each follow-up, pulmonary functions, fractional exhaled nitric oxide (FeNO), 7-day continuous personal exposure to airborne particles were measured. Multivariate linear mixed effect regression models were applied to investigate the quantitative changes of pulmonary functions and FeNO in two respective groups. The results showed that on average 4.7 follow-up visits were completed in each participant. In subjects with CRDs, an inter-quartile range (IQR) increase of personal exposure to PM(1.0), PM(2.5) and PM(10) was significantly associated with an average increase of FeNO(Lag1) of 6.7 ppb (95%CI 1.2, 9.9 ppb), 6.2 ppb (95%CI 1.5, 12.0 ppb) and 5.6 ppb (95%CI 1.5, 11.0 ppb), respectively, and an average decrease of FEV1(Lag2) of -3.6 L (95%CI -6.0, -1.1 L), -3.6 L (95%CI -6.4, -0.8 L) and -3.2 L (95%CI -5.8, -0.6 L), respectively, in the single-pollutant model. These associations remained consistent in the two-pollutant models adjusting for gaseous air pollutants. Stratified analysis showed that subjects with lower BMI, females and non-allergies were more sensitive to particle exposure. No robust significant effects were observed in the subjects without CRDs. Our study provided data on the susceptibility of the elderly with CRDs to particle exposure of PM(1.0) and PM(2.5), and the modification effects by BMI, gender and history of allergies. CI - Copyright (c) 2020 Elsevier Ltd. All rights reserved. FAU - Chen, Tianyi AU - Chen T AD - Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China. FAU - Chen, Fei'er AU - Chen F AD - Shanghai Municipal Center for Disease Control & Prevention, Shanghai, China. FAU - Wang, Kan AU - Wang K AD - Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China. FAU - Ma, Xuedong AU - Ma X AD - Shanghai Minhang District Gumei Community Health Center affiliated to Fudan University, Shanghai, 201102, China. FAU - Wei, Xinping AU - Wei X AD - Shanghai Minhang District Gumei Community Health Center affiliated to Fudan University, Shanghai, 201102, China. FAU - Wang, Weigang AU - Wang W AD - Shanghai Minhang District Gumei Community Health Center affiliated to Fudan University, Shanghai, 201102, China. FAU - Huang, Pengyu AU - Huang P AD - Shanghai Minhang District Gumei Community Health Center affiliated to Fudan University, Shanghai, 201102, China. FAU - Yang, Dong AU - Yang D AD - Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. FAU - Xia, Zhaolin AU - Xia Z AD - Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China. FAU - Zhao, Zhuohui AU - Zhao Z AD - Department of Environmental Health, School of Public Health, Fudan University, Shanghai, 200032, China; Key Laboratory of Public Health Safety of the Ministry of Education, NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai Typhoon Institute/CMA, Shanghai Key Laboratory of Meteorology and Health, Shanghai, 200030, China. Electronic address: zhzhao@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20201217 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Air Pollutants) RN - 0 (Particulate Matter) SB - IM MH - Aged MH - *Air Pollutants/analysis MH - *Air Pollution/adverse effects/analysis MH - *Asthma MH - China MH - Environmental Exposure/adverse effects/analysis MH - Female MH - Humans MH - Particulate Matter/analysis MH - *Pulmonary Disease, Chronic Obstructive OTO - NOTNLM OT - Asthma OT - Asthma COPD Overlap OT - COPD OT - Particulate matter OT - Personal air pollution COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Zhuohui Zhao declared that this study was funded by the National Key Basic Research Development Plan (2015CB553404) from China. All other co-authors declare no conflicts of interests. EDAT- 2020/12/29 06:00 MHDA- 2021/02/04 06:00 CRDT- 2020/12/28 20:06 PHST- 2020/04/09 00:00 [received] PHST- 2020/12/12 00:00 [revised] PHST- 2020/12/14 00:00 [accepted] PHST- 2020/12/29 06:00 [pubmed] PHST- 2021/02/04 06:00 [medline] PHST- 2020/12/28 20:06 [entrez] AID - S0269-7491(20)37018-4 [pii] AID - 10.1016/j.envpol.2020.116329 [doi] PST - ppublish SO - Environ Pollut. 2021 Feb 15;271:116329. doi: 10.1016/j.envpol.2020.116329. Epub 2020 Dec 17.