PMID- 33372377 OWN - NLM STAT- MEDLINE DCOM- 20211025 LR - 20240331 IS - 1475-097X (Electronic) IS - 1475-0961 (Print) IS - 1475-0961 (Linking) VI - 41 IP - 2 DP - 2021 Mar TI - Prognostic value of left atrial volume index in acute coronary syndrome: A systematic review and meta-analysis. PG - 128-135 LID - 10.1111/cpf.12689 [doi] AB - BACKGROUND: In the absence of mitral valve disease, increased left atrial volume (LAV) is a marker of diastolic dysfunction and long-standing elevated left ventricle (LV) pressure. The aim of this study was to assess the role of increased baseline LAV in predicting clinical outcome of patients presenting with acute coronary syndrome (ACS). METHODS: We systematically searched all electronic databases up to September 2020 in order to select clinical trials and observational studies, which assessed the predictive role of LAV indexed (LAVI) on clinical outcome in patients with ACS. Primary clinical endpoints were as follows: major adverse cardiac events (MACE), all-cause mortality and hospitalization. Secondary endpoints were in-hospital complications. RESULTS: A total of 2,705 patients from 11 cohort studies with a mean follow-up 18.7 +/- 9.8 months were included in the meta-analysis. Patients with low LAVI had low risk for MACE (15.9% vs. 33.7%; p < .01), long-term all-cause mortality (9.14% vs. 18.1%; p < .01), short-term mortality (3.31% vs. 9.38%; p = .02) and lower hospitalization rate (11.6% vs. 25.5%; p < .01) compared to patients with increased LAVI. Atrial fibrillation and cardiogenic shock as in-hospital events were lower (p < .05 for all) in patients with low LAVI but ventricular fibrillation/tachycardia was not different between groups (p = .14). CONCLUSION: Increased LAVI is an independent predictor of outcome in patients with ACS. Thus, assessment of LA index in these patients is important for better risk stratification and guidance towards optimum clinical management. CI - (c) 2020 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine. FAU - Ahmeti, Artan AU - Ahmeti A AD - Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo. AD - Medical Faculty, University of Prishtina, Prishtina, Kosovo. FAU - Bytyci, Feriz S AU - Bytyci FS AD - Main Family Medical Center, Prishtina, Kosovo. FAU - Bielecka-Dabrowa, Agata AU - Bielecka-Dabrowa A AD - Department of Hypertension, Medical University of Lodz, Lodz, Poland. FAU - Bytyci, Ibadete AU - Bytyci I AUID- ORCID: 0000-0002-8996-4257 AD - Clinic of Cardiology, University Clinical Centre of Kosovo, Prishtina, Kosovo. AD - Institute of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Henein, Michael Y AU - Henein MY AD - Institute of Public Health and Clinical Medicine, Umea University, Umea, Sweden. AD - Molecular and Clinic Research Institute, St George University, London, UK. AD - Brunel University, London, UK. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review PT - Systematic Review DEP - 20210112 PL - England TA - Clin Physiol Funct Imaging JT - Clinical physiology and functional imaging JID - 101137604 SB - IM MH - *Acute Coronary Syndrome/diagnostic imaging MH - *Atrial Fibrillation/diagnostic imaging MH - Heart Atria/diagnostic imaging MH - Humans MH - Prognosis MH - Risk Factors PMC - PMC7898886 OTO - NOTNLM OT - acute coronary syndrome OT - clinical outcome OT - left atrial volume COIS- The authors have no conflict of interest to declare. EDAT- 2020/12/30 06:00 MHDA- 2021/10/26 06:00 PMCR- 2021/02/22 CRDT- 2020/12/29 06:06 PHST- 2020/10/27 00:00 [received] PHST- 2020/12/09 00:00 [revised] PHST- 2020/12/21 00:00 [accepted] PHST- 2020/12/30 06:00 [pubmed] PHST- 2021/10/26 06:00 [medline] PHST- 2020/12/29 06:06 [entrez] PHST- 2021/02/22 00:00 [pmc-release] AID - CPF12689 [pii] AID - 10.1111/cpf.12689 [doi] PST - ppublish SO - Clin Physiol Funct Imaging. 2021 Mar;41(2):128-135. doi: 10.1111/cpf.12689. Epub 2021 Jan 12.