PMID- 33373387
OWN - NLM
STAT- MEDLINE
DCOM- 20210319
LR  - 20210319
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 15
IP  - 12
DP  - 2020
TI  - Resting-state functional connectivity and quantitation of glutamate and GABA of 
      the PCC/precuneus by magnetic resonance spectroscopy at 7T in healthy 
      individuals.
PG  - e0244491
LID - 10.1371/journal.pone.0244491 [doi]
LID - e0244491
AB  - The default mode network (DMN) is the main large-scale network of the resting 
      brain and the PCC/precuneus is a major hub of this network. Glutamate and GABA 
      (gamma-amino butyric acid) are the main excitatory and inhibitory neurotransmitters 
      in the CNS, respectively. We studied glutamate and GABA concentrations in the 
      PCC/precuneus via magnetic resonance spectroscopy (MRS) at 7T in relation to age 
      and correlated them with functional connectivity between this region and other 
      DMN nodes in ten healthy right-handed volunteers ranging in age between 23-68 
      years. Mean functional connectivity of the PCC/precuneus to the other DMN nodes 
      and the glutamate/GABA ratio significantly correlated with age (r = 0.802, p = 
      0.005 and r = 0.793, p = 0.006, respectively) but not with each other. Glutamate 
      and GABA alone did not significantly correlate with age nor with functional 
      connectivity within the DMN. The glutamate/GABA ratio and functional connectivity 
      of the PCC/precuneus are, therefore, independent age-related biomarkers of the 
      DMN and may be combined in a multimodal pipeline to study DMN alterations in 
      various disease states.
FAU - Gonen, Ofer M
AU  - Gonen OM
AUID- ORCID: 0000-0002-3833-9128
AD  - Department of Neurology, The Royal Melbourne Hospital, Victoria, Australia.
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
AD  - Department of Neurology, The Alfred Hospital, Victoria, Australia.
FAU - Moffat, Bradford A
AU  - Moffat BA
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
FAU - Kwan, Patrick
AU  - Kwan P
AD  - Department of Neurology, The Royal Melbourne Hospital, Victoria, Australia.
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
AD  - Department of Neurology, The Alfred Hospital, Victoria, Australia.
AD  - Department of Neuroscience, Central Clinical School, Monash University, Victoria, 
      Australia.
FAU - O'Brien, Terence J
AU  - O'Brien TJ
AD  - Department of Neurology, The Royal Melbourne Hospital, Victoria, Australia.
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
AD  - Department of Neurology, The Alfred Hospital, Victoria, Australia.
AD  - Department of Neuroscience, Central Clinical School, Monash University, Victoria, 
      Australia.
FAU - Desmond, Patricia M
AU  - Desmond PM
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
AD  - Department of Radiology, The Royal Melbourne Hospital, Victoria, Australia.
FAU - Lui, Elaine
AU  - Lui E
AD  - Department of Medicine and Radiology, The University of Melbourne, Victoria, 
      Australia.
AD  - Department of Radiology, The Royal Melbourne Hospital, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20201229
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Brain Mapping/methods
MH  - Female
MH  - Glutamic Acid/*analysis/metabolism
MH  - Healthy Volunteers
MH  - Humans
MH  - Magnetic Resonance Spectroscopy/methods
MH  - Male
MH  - Middle Aged
MH  - Multiparametric Magnetic Resonance Imaging/methods
MH  - Nerve Net/diagnostic imaging/*physiology
MH  - Parietal Lobe/diagnostic imaging/*metabolism
MH  - Rest/*physiology
MH  - Young Adult
MH  - gamma-Aminobutyric Acid/*analysis/metabolism
PMC - PMC7771854
COIS- The authors have declared that no competing interests exist.
EDAT- 2020/12/30 06:00
MHDA- 2021/03/20 06:00
PMCR- 2020/12/29
CRDT- 2020/12/29 17:08
PHST- 2020/04/28 00:00 [received]
PHST- 2020/12/10 00:00 [accepted]
PHST- 2020/12/29 17:08 [entrez]
PHST- 2020/12/30 06:00 [pubmed]
PHST- 2021/03/20 06:00 [medline]
PHST- 2020/12/29 00:00 [pmc-release]
AID - PONE-D-20-12377 [pii]
AID - 10.1371/journal.pone.0244491 [doi]
PST - epublish
SO  - PLoS One. 2020 Dec 29;15(12):e0244491. doi: 10.1371/journal.pone.0244491. 
      eCollection 2020.