PMID- 33374413
OWN - NLM
STAT- MEDLINE
DCOM- 20210913
LR  - 20210913
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Dec 24
TI  - Tracking the Genetic Susceptibility Background of B-Cell Non-Hodgkin's Lymphomas 
      from Genome-Wide Association Studies.
LID - 10.3390/ijms22010122 [doi]
LID - 122
AB  - B-cell non-Hodgkin's lymphoma (NHL) risk associations had been mainly attributed 
      to family history of the disease, inflammation, and immune components including 
      human leukocyte antigen (HLA) genetic variations. Nevertheless, a broad range of 
      genome-wide association studies (GWAS) have shed light into the identification of 
      several genetic variants presumptively associated with B-cell NHL etiologies, 
      survival or shared genetic risk with other diseases. The present review aims to 
      overview HLA structure and diversity and summarize the evidence of genetic 
      variations, by GWAS, on five NHL subtypes (diffuse large B-cell lymphoma DLBCL, 
      follicular lymphoma FL, chronic lymphocytic leukemia CLL, marginal zone lymphoma 
      MZL, and primary central nervous system lymphoma PCNSL). Evidence indicates that 
      the HLA zygosity status in B-cell NHL might promote immune escape and that 
      genome-wide significance variants can give biological insight but also potential 
      therapeutic markers such as WEE1 in DLBCL. However, additional studies are 
      needed, especially for non-DLBCL, to replicate the associations found to date.
FAU - Hernandez-Verdin, Isaias
AU  - Hernandez-Verdin I
AD  - Faculte de Medecine, Sorbonne Universite, 75013 Paris, France.
AD  - Brain and Spine Institute (ICM), 75013 Paris, France.
FAU - Labreche, Karim
AU  - Labreche K
AD  - Faculte de Medecine, Sorbonne Universite, 75013 Paris, France.
AD  - Brain and Spine Institute (ICM), 75013 Paris, France.
FAU - Benazra, Marion
AU  - Benazra M
AD  - Faculte de Medecine, Sorbonne Universite, 75013 Paris, France.
AD  - Brain and Spine Institute (ICM), 75013 Paris, France.
AD  - National Institute of Health and Medical Research (Inserm) U 1127, 75013 Paris, 
      France.
AD  - National Center for Scientific Research, Joint Research Unit 7225, 75013 Paris, 
      France.
AD  - ICM, iGenSeq Platform, 75013 Paris, France.
FAU - Mokhtari, Karima
AU  - Mokhtari K
AD  - Raymond Escourolle Department of Neuropathology, Public Assistance-Hospitals of 
      Paris, Hospital Group of Pitie-Salpetriere, 75013 Paris, France.
AD  - APHP, Department of Neurology-2, Groupe Hospitalier Pitie Salpetriere, 75013 
      Paris, France.
FAU - Hoang-Xuan, Khe
AU  - Hoang-Xuan K
AD  - Faculte de Medecine, Sorbonne Universite, 75013 Paris, France.
AD  - Brain and Spine Institute (ICM), 75013 Paris, France.
AD  - National Institute of Health and Medical Research (Inserm) U 1127, 75013 Paris, 
      France.
AD  - National Center for Scientific Research, Joint Research Unit 7225, 75013 Paris, 
      France.
AD  - APHP, Department of Neurology-2, Groupe Hospitalier Pitie Salpetriere, 75013 
      Paris, France.
AD  - Reseau Expert National LOC (Lymphomes Oculo-Cerebraux), Groupe Hospitalier Pitie 
      Salpetriere, 75013 Paris, France.
FAU - Alentorn, Agusti
AU  - Alentorn A
AD  - Faculte de Medecine, Sorbonne Universite, 75013 Paris, France.
AD  - Brain and Spine Institute (ICM), 75013 Paris, France.
AD  - National Institute of Health and Medical Research (Inserm) U 1127, 75013 Paris, 
      France.
AD  - National Center for Scientific Research, Joint Research Unit 7225, 75013 Paris, 
      France.
AD  - APHP, Department of Neurology-2, Groupe Hospitalier Pitie Salpetriere, 75013 
      Paris, France.
LA  - eng
GR  - PRT-K grant 2017-1-RT-04/DGOS / INCa/
GR  - ANR-18-RHUS-0012/Agence Nationale de la Recherche/
PT  - Journal Article
PT  - Review
DEP - 20201224
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (HLA Antigens)
RN  - 0 (Lipids)
SB  - IM
MH  - Central Nervous System Neoplasms/*genetics
MH  - Genetic Background
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - HLA Antigens/metabolism
MH  - Humans
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/*genetics
MH  - Lipids/chemistry
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics
MH  - Lymphoma, Follicular/*genetics
MH  - Lymphoma, Large B-Cell, Diffuse/*genetics
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Risk
MH  - Risk Factors
PMC - PMC7795678
OTO - NOTNLM
OT  - B-cell non-Hodgkin's lymphoma
OT  - GWAS
OT  - HLA
OT  - cancer risk
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/31 06:00
MHDA- 2021/09/14 06:00
PMCR- 2020/12/24
CRDT- 2020/12/30 01:01
PHST- 2020/11/05 00:00 [received]
PHST- 2020/12/10 00:00 [revised]
PHST- 2020/12/18 00:00 [accepted]
PHST- 2020/12/30 01:01 [entrez]
PHST- 2020/12/31 06:00 [pubmed]
PHST- 2021/09/14 06:00 [medline]
PHST- 2020/12/24 00:00 [pmc-release]
AID - ijms22010122 [pii]
AID - ijms-22-00122 [pii]
AID - 10.3390/ijms22010122 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Dec 24;22(1):122. doi: 10.3390/ijms22010122.