PMID- 33375370
OWN - NLM
STAT- MEDLINE
DCOM- 20210907
LR  - 20210907
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 22
IP  - 1
DP  - 2020 Dec 26
TI  - Finely-Tuned Calcium Oscillations in Osteoclast Differentiation and Bone 
      Resorption.
LID - 10.3390/ijms22010180 [doi]
LID - 180
AB  - Calcium (Ca(2+)) plays an important role in regulating the differentiation and 
      function of osteoclasts. Calcium oscillations (Ca oscillations) are well-known 
      phenomena in receptor activator of nuclear factor kappa B ligand (RANKL)-induced 
      osteoclastogenesis and bone resorption via calcineurin. Many modifiers are 
      involved in the fine-tuning of Ca oscillations in osteoclasts. In addition to 
      macrophage colony-stimulating factors (M-CSF; CSF-1) and RANKL, costimulatory 
      signaling by immunoreceptor tyrosine-based activation motif-harboring adaptors is 
      important for Ca oscillation generation and osteoclast differentiation. 
      DNAX-activating protein of 12 kD is always necessary for osteoclastogenesis. In 
      contrast, Fc receptor gamma (FcRgamma) works as a key controller of 
      osteoclastogenesis especially in inflammatory situation. FcRgamma has a cofactor in 
      fine-tuning of Ca oscillations. Some calcium channels and transporters are also 
      necessary for Ca oscillations. Transient receptor potential (TRP) channels are 
      well-known environmental sensors, and TRP vanilloid channels play an important 
      role in osteoclastogenesis. Lysosomes, mitochondria, and endoplasmic reticulum 
      (ER) are typical organelles for intracellular Ca(2+) storage. Ryanodine receptor, 
      inositol trisphosphate receptor, and sarco/endoplasmic reticulum Ca(2+) ATPase on 
      the ER modulate Ca oscillations. Research on Ca oscillations in osteoclasts has 
      still many problems. Surprisingly, there is no objective definition of Ca 
      oscillations. Causality between Ca oscillations and osteoclast differentiation 
      and/or function remains to be examined.
FAU - Okada, Hiroyuki
AU  - Okada H
AUID- ORCID: 0000-0003-4217-1548
AD  - Department of Orthopaedic Surgery, The University of Tokyo, Tokyo 113-8655, 
      Japan.
AD  - Center of Disease Biology and Integrative Medicine, Graduate School of Medicine, 
      The University of Tokyo, Tokyo 113-8655, Japan.
FAU - Okabe, Koji
AU  - Okabe K
AD  - Department of Physiological Science and Molecular Biology, Fukuoka Dental 
      College, Fukuoka 814-0193, Japan.
FAU - Tanaka, Sakae
AU  - Tanaka S
AD  - Department of Orthopaedic Surgery, The University of Tokyo, Tokyo 113-8655, 
      Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201226
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Calcium Channels)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Bone Resorption/metabolism/*pathology
MH  - Calcium/*metabolism
MH  - Calcium Channels/*metabolism
MH  - *Calcium Signaling
MH  - *Cell Differentiation
MH  - Humans
MH  - Osteoclasts/*cytology/metabolism
MH  - *Osteogenesis
PMC - PMC7794828
OTO - NOTNLM
OT  - calcium oscillation
OT  - costimulatory signal
OT  - immunoreceptor tyrosine-based activation motif (ITAM)
OT  - osteoclast
OT  - receptor activator of nuclear factor kappa B ligand (RANKL)
OT  - transient receptor potential (TRP) channel
COIS- The authors declare no conflict of interest.
EDAT- 2020/12/31 06:00
MHDA- 2021/09/08 06:00
PMCR- 2020/12/26
CRDT- 2020/12/30 01:04
PHST- 2020/11/11 00:00 [received]
PHST- 2020/12/22 00:00 [revised]
PHST- 2020/12/23 00:00 [accepted]
PHST- 2020/12/30 01:04 [entrez]
PHST- 2020/12/31 06:00 [pubmed]
PHST- 2021/09/08 06:00 [medline]
PHST- 2020/12/26 00:00 [pmc-release]
AID - ijms22010180 [pii]
AID - ijms-22-00180 [pii]
AID - 10.3390/ijms22010180 [doi]
PST - epublish
SO  - Int J Mol Sci. 2020 Dec 26;22(1):180. doi: 10.3390/ijms22010180.