PMID- 33376592
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201231
IS  - 2090-8040 (Print)
IS  - 2042-0099 (Electronic)
IS  - 2042-0099 (Linking)
VI  - 2020
DP  - 2020
TI  - The Influence of Vitamin D Receptor Gene Polymorphisms in Spondyloarthritis.
PG  - 8880879
LID - 10.1155/2020/8880879 [doi]
LID - 8880879
AB  - Spondyloarthritis (SpA) is an inflammatory rheumatic disease related to low bone 
      mineral density. Because vitamin D plays an important role in bone metabolism and 
      immune system modulation, the aim of this study was to evaluate the influence of 
      polymorphisms in vitamin D receptor genes (VDR) in the development of SpA. In 
      this case-control study, a total of 244 patients with SpA and 197 individuals 
      with no SpA were included. Among the patients, 174 had ankylosing spondylitis 
      (AS) and 66 had psoriatic arthritis (PsA). Genotyping of FokI (rs2228570 C > T), 
      BsmI (rs1544410 C > T), ApaI (rs7975232 A > C), and TaqI (rs731236 T > C) was 
      performed using PCR-RFLP, while genotyping of HLA-B *27 was performed using 
      PCR-SSP. Serum levels for hydroxy (OH) vitamin D and the clinical activity index 
      of the disease (BASDAI) were also evaluated. SNPStats and OpenEpi software were 
      used for statistical analysis. The ApaI a allele and ApaI a/a genotype were less 
      frequent in PsA compared with controls. The ApaI a/a genotype was associated with 
      a protecting factor for PsA in females, and ApaI A/a was associated with a 
      protecting factor for the disease in HLA-B *27 positive patients. Notwithstanding, 
      the ApaI a/a genotype was a risk factor for SpA and AS in males. The FokI f/f 
      genotype was associated with a better clinical activity in PsA. When considering 
      the covariates, vitamin D sufficiency, and gender, the FokI F/F genotype was 
      associated with a risk factor in males with SpA and AS compared with females with 
      this same genotype. In conclusion, the ApaI rs7975232 polymorphism was associated 
      with PsA, and the FokI rs2228570 polymorphism was associated with better clinical 
      PsA activity. ApaI and FokI were associated with SpA and AS when considering 
      gender and vitamin D sufficiency.
CI  - Copyright (c) 2020 Janisleya Silva Ferreira Neves et al.
FAU - Neves, Janisleya Silva Ferreira
AU  - Neves JSF
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - Visentainer, Jeane Eliete Laguila
AU  - Visentainer JEL
AUID- ORCID: 0000-0002-5815-7903
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
AD  - Department of Basic and Health Science, Maringa State University, Parana, Brazil.
FAU - Reis, Denise Manjurma da Silva
AU  - Reis DMDS
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - Rocha Loures, Marco Antonio
AU  - Rocha Loures MA
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
AD  - Department of Medicine, Maringa State University, Parana, Brazil.
FAU - Alves, Hugo Vicentin
AU  - Alves HV
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - Lara-Armi, Fernanda Formaggi
AU  - Lara-Armi FF
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - de Alencar, Josiane Bazzo
AU  - de Alencar JB
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - Valentin Zacarias, Joana Maira
AU  - Valentin Zacarias JM
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
FAU - Sell, Ana Maria
AU  - Sell AM
AUID- ORCID: 0000-0001-7315-3567
AD  - Biosciences and Physiopathology, Department of Clinical Analysis and Biomedicine, 
      Maringa State University, Parana, Brazil.
AD  - Department of Basic and Health Science, Maringa State University, Parana, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20201208
PL  - United States
TA  - Int J Inflam
JT  - International journal of inflammation
JID - 101538188
PMC - PMC7738787
COIS- The authors declare that there are no conflicts of interest regarding the 
      publication of this article.
EDAT- 2020/12/31 06:00
MHDA- 2020/12/31 06:01
PMCR- 2020/12/08
CRDT- 2020/12/30 05:21
PHST- 2020/07/22 00:00 [received]
PHST- 2020/10/10 00:00 [revised]
PHST- 2020/11/28 00:00 [accepted]
PHST- 2020/12/30 05:21 [entrez]
PHST- 2020/12/31 06:00 [pubmed]
PHST- 2020/12/31 06:01 [medline]
PHST- 2020/12/08 00:00 [pmc-release]
AID - 10.1155/2020/8880879 [doi]
PST - epublish
SO  - Int J Inflam. 2020 Dec 8;2020:8880879. doi: 10.1155/2020/8880879. eCollection 
      2020.