PMID- 33378991
OWN - NLM
STAT- MEDLINE
DCOM- 20210224
LR  - 20210224
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 133
DP  - 2021 Jan
TI  - Dendritic cells in pregnancy and pregnancy-associated diseases.
PG  - 110921
LID - S0753-3322(20)31113-6 [pii]
LID - 10.1016/j.biopha.2020.110921 [doi]
AB  - Dendritic cells (DCs) play a critical immuno-modulating role in pregnancy, which 
      requires the maternal immune system to tolerate semiallogeneic fetus and at the 
      same time to maintain adequate defense against pathogens. DCs interact closely 
      with other immune components such as T cells, natural killer cells and 
      macrophages, as well as the endocrine system to keep a pregnancy-friendly 
      environment. Aberrant DC activities have been related to various 
      pregnancy-associated diseases such as recurrent spontaneous abortion, preterm 
      birth, pre-eclampsia, peripartum cardiomyopathy and infectious pregnancy 
      complications. These findings make DCs an attractive candidate for prevention or 
      therapy on the pregnancy-associated diseases. Here, we review recent findings 
      that provide new insights into the roles of DCs in pregnancy and the related 
      diseases. We also discuss the medical potentials to manipulate DCs in clinics. 
      Whereas this is an emerging area with much work remaining, we anticipate that a 
      better understanding of the role of DCs in maternal-fetal immunotolerance and a 
      therapeutic manipulation of DCs will help women suffering from the 
      pregnancy-associated diseases.
CI  - Copyright (c) 2020 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Wei, Ran
AU  - Wei R
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Lai, Nannan
AU  - Lai N
AD  - Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen 
      University, Shenzhen, Guangdong, PR China.
FAU - Zhao, Lin
AU  - Zhao L
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Zhang, Zhen
AU  - Zhang Z
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Zhu, Xiaoxiao
AU  - Zhu X
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Guo, Qiang
AU  - Guo Q
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Chu, Chu
AU  - Chu C
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Fu, Xiaoxiao
AU  - Fu X
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China.
FAU - Li, Xia
AU  - Li X
AD  - Laboratory for Molecular Immunology, Institute of Basic Medicine, Shandong 
      Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 
      Shandong, PR China. Electronic address: lixia@sdfmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20201128
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
SB  - IM
MH  - Adoptive Transfer
MH  - Animals
MH  - Dendritic Cells/*immunology/metabolism/transplantation
MH  - Female
MH  - Genetic Therapy
MH  - *Histocompatibility, Maternal-Fetal/genetics
MH  - Humans
MH  - *Immune Tolerance/genetics
MH  - Maternal-Fetal Exchange/genetics/*immunology
MH  - Pregnancy
MH  - Pregnancy Complications/genetics/*immunology/metabolism/prevention & control
MH  - Risk Factors
MH  - Signal Transduction
OTO - NOTNLM
OT  - Dendritic cells
OT  - Immunotolerance
OT  - Maternal-fetal interface
OT  - Pregnancy
OT  - Pregnancy-associated diseases
EDAT- 2021/01/01 06:00
MHDA- 2021/02/25 06:00
CRDT- 2020/12/31 01:00
PHST- 2020/08/23 00:00 [received]
PHST- 2020/10/18 00:00 [revised]
PHST- 2020/10/20 00:00 [accepted]
PHST- 2020/12/31 01:00 [entrez]
PHST- 2021/01/01 06:00 [pubmed]
PHST- 2021/02/25 06:00 [medline]
AID - S0753-3322(20)31113-6 [pii]
AID - 10.1016/j.biopha.2020.110921 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 Jan;133:110921. doi: 10.1016/j.biopha.2020.110921. Epub 
      2020 Nov 28.